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Cat. No.: HY-P12357

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CD27 peptide

CD27 peptide is a 13-amino acid peptide derived from CD27. CD27 peptide is a targeting ligand for CD70 and can be used to construct CD70-targeted peptide amphiphile micelles. CD27 peptide can be used for research on melanoma and clear cell renal cell carcinoma.

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CAS No.: 3037125-72-4
Formule: C₅₄H₉₂N₁₈O₁₇S₃
Masse moléculaire:1361.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

CD27 peptide Chemical Structure

CAS No.: 3037125-72-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

CD27 peptide (99:1 peptide:siRNA ratio; 1 h) incorporation into HIF2α-CD27 PAMs successfully retains HIF2α siRNA and protects it from RNase degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Increased Ova(I)-specific CD8+ T cells from ~20% to ~50% of the CD8+ TIL population.
Extended median survival by 18 days compared to control animals.\nProlonged survival in the setting of vaccines comprised of linked class I and II epitopes (Ova(I-IIA)).
Had no effect on survival with Ova(I) or Ova(I) + Ova(IIA) vaccines.\nProlonged survival in hCD27 mice bearing intracranial B16.OVA tumors.

Animal Model:

C57BL/6 (Female human CD27 transgenic (hCD27), aged 6-12 weeks)^[2]
Dosage:

100 µg
Administration:

i.p.; on days 3 and 6 after tumor implantation
Result:

Prolonged survival in mice bearing 3-day established intracranial B16.F10 tumors when combined with Trp2(I)-P30.
Had no effect on survival relative to control groups when combined with Trp2(I).

Chemical Information

CAS No. 3037125-72-4
Masse moléculaire 1361.61
Formule C₅₄H₉₂N₁₈O₁₇S₃
Sequence

Cys-Arg-Lys-Ala-Ala-Gln-Cys-Asp-Pro-Cys-Ile-Pro-Gly
Sequence Shortening

CRKAAQCDPCIPG
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Trac N, et al. CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells. Molecules (Basel, Switzerland). 2022 Dec 02;27(23):8457.

[2]. Riccione KA, et al. CD27 stimulation unveils the efficacy of linked class I/II peptide vaccines in poorly immunogenic tumors by orchestrating a coordinated CD4/CD8 T cell response. Oncoimmunology. 2018 Sep 5;7(12):e1502904.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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