Cat. No.: HY-108434

Ceapin-A7

24 Cited Publications

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Based on 24 publication(s) in Google Scholar

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC₅₀ of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

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Pureté: 99.95%
CAS No.: 2323027-38-7
Formule: C₂₀H₁₂F₆N₄O₃
Masse moléculaire:470.32

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 2 years , -20°C, 1 year

Ceapin-A7 Chemical Structure

CAS No.: 2323027-38-7

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (24)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target

0.59 μM (ATF6α)^[1]

In Vitro

Ceapin-A7 sensitizes cells to ER stress^[1].
Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2323027-38-7
Appearance Solid
Masse moléculaire 470.32
Formule C₂₀H₁₂F₆N₄O₃
Color Off-white to light yellow
SMILES

O=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (24)

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Journal Impact Factor

Signal Transduct Target Ther

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation. [Abstract]

2024 Dec 30;9(1):367. PMID: 39737965

Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367. [Abstract]

Il1b, Tnfa, or Il6 mRNA expressions in LPS-stimulated BMDMs treated with/without L-malate (24 h) in the presence or absence of CEAPIN-A7 (CEAPIN, 8 μM).
Cancer Res

Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers. [Abstract]

2021 Oct 15;81(20):5325-5335. PMID: 34548333
J Hazard Mater

A new insight into Cd exposure-induced hemocyte reduction in Lymantria dispar larvae: Involvement of the ROS-ATF6-ER stress-apoptosis pathway. [Abstract]

2024 May 5:469:134061. PMID: 38508113
Cell Mol Biol Lett

Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress. [Abstract]

2022 Dec 16;27(1):110. PMID: 36526973

Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2022 Dec 16;27(1):110. [Abstract]

Immunoblot of GRP78 and CHOP under insulin and PA combined treatment with or without pre-treatment of ATF6α inhibitor Ceapin-A7 (6 μM), PERK inhibitor ISRIB (0.2 μM) and IRE1 inhibitor 4μ8C (50 μM).
J Transl Med

Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer. [Abstract]

2025 Aug 5;23(1):860. PMID: 40764992

Ceapin-A7 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Aug 5;23(1):860. [Abstract]

ATF6 inhibition abolished the effect of RAD51 down-regulation mediated by IVA. 5 μM of ATF6 inhibitor Ceapin-A7, 0.1 µM of IVA and 5 μM of OLA were used. The cells were treated for 72 h. Western blot was performed. HSP90 was the loading control. the results showed that Ceapin-A7 increased RAD51-EGFP levels.
Cell Death Discov

Inhibiting HSP27 activates the XBP1s/CerS1 interplay, which triggers DRP1-driven mitophagy, thereby protecting against cell death and promoting the KSHV lytic cycle in primary effusion lymphoma cells. [Abstract]

2026 Feb 26. PMID: 41748537
Mol Med

MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway. [Abstract]

2024 Nov 29;30(1):237. PMID: 39614150

Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237. [Abstract]

After treating with Ceapin-A7 (6 µM) for 1 h and stimulating with rhMIF for 3 days, flow cytometry was used to analyze the effect of Ceapin-A7 on Th17 cells. *ρ < 0.05

Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237. [Abstract]

The expression of ATF6α, STAT3, and RORC in RA patient cells stimulated with rhMIF in the presence of Ceapin-A7 （6 µM; 1 h）.
Liver Int

Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases protein degradation mediated by the proteasome. [Abstract]

2024 May;44(5):1219-1232. PMID: 38375985
Int J Mol Sci

Cartilage Intermediate Layer Protein 2 Aggravates Hepatic Lipid Accumulation and Inflammation Through the IRE1α/XBP1 Pathway. [Abstract]

2026 Jan 25;27(3):1213. PMID: 41683641
Biomolecules

2026 Apr;16(4):506.
mBio

Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication. [Abstract]

2025 Dec 5:e0324225. PMID: 41347792
Toxicology

Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]

2024 Aug 6:153906. PMID: 39117261
Fish Shellfish Immunol

Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication. [Abstract]

2024 Nov 9:155:110020. PMID: 39528019
Cytokine

Triptolide impacts CSF1R expression and reprograms the suppressive function of myeloid-derived suppressor cells via targeting the ER stress pathway. [Abstract]

2026 Jan:197:157068. PMID: 41197245
Cell Signal

Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]

2024 Dec 8:127:111560. PMID: 39657838
Am J Pathol

R-Propranolol Promotes the Adipogenesis and Subsequent Apoptosis of Hemangioma Stem Cells through the Protein Kinase RNA-Like Endoplasmic Reticulum Kinase Signaling Pathway. [Abstract]

2026 Mar 19:S0002-9440(26)00065-9. PMID: 41864339
Am J Pathol

Sleep Deprivation Impairs Intestinal Mucosal Barrier by Activating Endoplasmic Reticulum Stress in Goblet Cells. [Abstract]

2024 Jan;194(1):85-100. PMID: 37918798
Vet Microbiol

Bovine parainfluenza virus type 3 infections induce ER stress-mediated autophagy to facilitate virus replication. [Abstract]

2024 May:292:110051. PMID: 38513524
Biochem Biophys Res Commun

Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis. [Abstract]

2024 Nov 12:733:150716. PMID: 39321486
bioRxiv

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING. [Abstract]

2026 May 29:2026.05.26.727520. PMID: 42244578
bioRxiv

The active secretion of a subunit of IL-12 by tissue cells is regulated by Valosin-Containing Protein and intracellular calcium redistribution. [Abstract]

2026 Feb 1:2026.01.28.702376. PMID: 41659431
bioRxiv

2026 Feb 24.
Temple University

2025.
bioRxiv

2024 August 28.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (212.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1262 mL

10.6311 mL

21.2621 mL

5 mM

0.4252 mL

2.1262 mL

4.2524 mL

10 mM

0.2126 mL

1.0631 mL

2.1262 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (5.32 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 15% Cremophor EL 85% Saline

Solubility: 12.5 mg/mL (26.58 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ciara M Gallagher, et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife. 2016; 5: e11878. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1262 mL	10.6311 mL	21.2621 mL	53.1553 mL
	5 mM	0.4252 mL	2.1262 mL	4.2524 mL	10.6311 mL
	10 mM	0.2126 mL	1.0631 mL	2.1262 mL	5.3155 mL
	15 mM	0.1417 mL	0.7087 mL	1.4175 mL	3.5437 mL
	20 mM	0.1063 mL	0.5316 mL	1.0631 mL	2.6578 mL
	25 mM	0.0850 mL	0.4252 mL	0.8505 mL	2.1262 mL
	30 mM	0.0709 mL	0.3544 mL	0.7087 mL	1.7718 mL
	40 mM	0.0532 mL	0.2658 mL	0.5316 mL	1.3289 mL
	50 mM	0.0425 mL	0.2126 mL	0.4252 mL	1.0631 mL
	60 mM	0.0354 mL	0.1772 mL	0.3544 mL	0.8859 mL
	80 mM	0.0266 mL	0.1329 mL	0.2658 mL	0.6644 mL
	100 mM	0.0213 mL	0.1063 mL	0.2126 mL	0.5316 mL

Keywords

Ceapin-A7

24 Cited Publications

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Ceapin-A7

Cell Cycle/DNA Damage Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Transcription Factor-Targeted Library

Targeted Diversity Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Ceapin-A7

Activité biologique

Chemical Information

Publications (24)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Ceapin-A7

Cell Cycle/DNA Damage Compound Library

Anti-Aging Compound Library

Endoplasmic Reticulum Stress Compound Library

Transcription Factor-Targeted Library

Targeted Diversity Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Ceapin-A7

Activité biologique

Chemical Information

Publications (24)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Ceapin-A7 Related Classifications

Cat. No.: HY-108434