CGP-75355
CGP-75355 is an inhibitor of HIV-1 protease with IC50 of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.
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- CAS No.: 191594-64-6
- Formule: C39H53N5O7
- Masse moléculaire:703.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT2 | ED50 |
0.7 nM
Compound: 25a
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Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.
Concentration required to inhibit 50% of RT production in HIV-1/MN-infected MT-2 cells.
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[PMID: 9719591] |
| MT2 | IC50 |
58 nM
Compound: 25a
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The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
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[PMID: 9719591] |
Chemical Information
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CAS No. 191594-64-6
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Masse moléculaire 703.87
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Formule C39H53N5O7
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SMILES
CC(C)(C)[C@@H](C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC2=CC=C(C3=CC=CC=C3)C=C2)=O)NC(OC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Bold, G., et al., (1998). New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development. Journal of medicinal chemistry, 41(18), 3387-3401. [Content Brief]
[2]. Wieslaw M. Kazmierski, (2011). Antiviral Drugs: From Basic Discovery Through Clinical Trials.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGP-75355 Related Classifications
HY-117559 Related Classifications
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