CGP78850
Based on 2 publication(s) in Google Scholar
CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.47%
- CAS No.: 258326-83-9
- Formule: C36H46N5O9P
- Masse moléculaire:723.75
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CGP78850
More
Activité biologique
Grb2 SH2-phosphopeptide[1]
CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468 cells
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Concentration:0~100 μM
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Incubation Time:90 minutes
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Result:Reduced the amount of associated Grb2 protein in a dose-dependent manner.
Chemical Information
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CAS No. 258326-83-9
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Appearance Solid
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Masse moléculaire 723.75
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Formule C36H46N5O9P
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Color White to off-white
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SMILES
O=P(O)(O)CC(C=C1)=CC=C1C[C@H](NC(C)=O)C(NC2(CCCCC2)C(N[C@@H](CC(N)=O)C(NCCCC3=C(O)C=CC4=C3C=CC=C4)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Arch Dermatol Res
IL-22-mediated microRNA-124-3p/GRB2 axis regulates hyperproliferation and inflammatory response of keratinocytes in psoriasis. [Abstract]2025 Jan 10;317(1):227. PMID: 39792268
Solvant et solubilité
DMSO : ≥ 100 mg/mL (138.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3817 mL | 6.9085 mL | 13.8169 mL | 34.5423 mL |
| 5 mM | 0.2763 mL | 1.3817 mL | 2.7634 mL | 6.9085 mL | |
| 10 mM | 0.1382 mL | 0.6908 mL | 1.3817 mL | 3.4542 mL | |
| 15 mM | 0.0921 mL | 0.4606 mL | 0.9211 mL | 2.3028 mL | |
| 20 mM | 0.0691 mL | 0.3454 mL | 0.6908 mL | 1.7271 mL | |
| 25 mM | 0.0553 mL | 0.2763 mL | 0.5527 mL | 1.3817 mL | |
| 30 mM | 0.0461 mL | 0.2303 mL | 0.4606 mL | 1.1514 mL | |
| 40 mM | 0.0345 mL | 0.1727 mL | 0.3454 mL | 0.8636 mL | |
| 50 mM | 0.0276 mL | 0.1382 mL | 0.2763 mL | 0.6908 mL | |
| 60 mM | 0.0230 mL | 0.1151 mL | 0.2303 mL | 0.5757 mL | |
| 80 mM | 0.0173 mL | 0.0864 mL | 0.1727 mL | 0.4318 mL | |
| 100 mM | 0.0138 mL | 0.0691 mL | 0.1382 mL | 0.3454 mL |
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