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Cat. No.: HY-117435

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CIDD 0067106

CIDD-0067106 is a selective mTORC1 pathway inhibitor targeting androgen receptor-positive (AR+) triple-negative breast cancer (TNBC). CIDD-0067106 demonstrates potent inhibition of AR+ TNBC cell lines with an GI₅₀ value of 0.8 μM. CIDD-0067106 is promising for research of AR+ TNBC.

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CAS No.: 2151865-39-1
Formule: C₂₆H₂₉N₃O₄
Masse moléculaire:447.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CIDD 0067106 Chemical Structure

CAS No.: 2151865-39-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

mTORC1

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Cellular Effect

Cell Line	Type	Value	Description	References
A10	GI₅₀	35 μM Compound: 30	Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against rat A10 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
BT-549	GI₅₀	40 μM Compound: 30	Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human BT549 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1806	GI₅₀	30 μM Compound: 30	Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1806 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
HCC1937	GI₅₀	35 μM Compound: 30	Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human HCC1937 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-231	GI₅₀	50 μM Compound: 30	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
MDA-MB-453	GI₅₀	0.8 μM Compound: 30	Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human MDA-MB-453 cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]
SUM185PE	GI₅₀	1.6 μM Compound: 30	Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method Cytotoxicity against human SUM185PE cells assessed as growth inhibition incubated for 48 to 96 hrs by SRB method	[PMID: 29053266]

Chemical Information

CAS No. 2151865-39-1
Masse moléculaire 447.54
Formule C₂₆H₂₉N₃O₄
SMILES

C(C1=CC=C(C=2OC(=CN2)C3=CC=C(OCC=C(C)C)C=C3)N=C1)N4[C@H](C(OC)=O)CCC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Robles AJ, et al. Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells. J Med Chem. 2017 Nov 22;60(22):9275-9289. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
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CIDD 0067106

Voir tous les produits spécifiques à Isoform mTOR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CIDD 0067106 Related Classifications

HY-117435 Related Classifications