CN045
CN045 is a blood-brain barrier-permeable, selective M1 muscarinic receptor ligand with an IC50 value of 1 μM. CN045 enhances remyelination in mouse brain regions. CN045 can be used in studies related to multiple sclerosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 401809-27-6
- Formule: C16H22Cl3NO2
- Masse moléculaire:366.71
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mAChR1 1 μM (IC50) |
In Vitro
CN045 (5 days) potently stimulates differentiation of primary mouse OPCs into mature, myelin protein-expressing oligodendrocytes with an EC50 of 0.04 μM[2].
CN045 (1 μM; 14 days) promotes myelin-like ensheathment of engineered nanofibers by primary mouse OPCs, increasing both oligodendrocyte numbers and ensheathment length[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57/BL/6J (8-week-old male; multiple sclerosis model via 12 weeks of 0.3% cuprizone chow plus daily i.p. sirolimus 10 mg/kg-induced demyelination)[2]
-
Dosage:10 mg/kg
-
Administration:i.p.; daily; 6 weeks
-
Result:Increased remyelination in the corpus callosum, hippocampus, and cerebral cortex compared to vehicle treatment.
Increased the number of PPD+ myelinated axons per unit area in the corpus callosum.
Increased the percentage area of PLP staining in the hippocampus.
Increased the percentage area of PLP staining in the cerebral cortex.
Chemical Information
-
CAS No. 401809-27-6
-
Masse moléculaire 366.71
-
Formule C16H22Cl3NO2
-
SMILES
ClC1=C(OCCOCCN2CCC(C)CC2)C(Cl)=CC(Cl)=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CN045 Related Classifications
HY-187683 Related Classifications
Powered by Bioz