Dihydrostreptomycin
Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss.
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- CAS No.: 128-46-1
- Formule: C23H45N7O12
- Masse moléculaire:611.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Dihydrostreptomycin blocks mechanoelectric transduction channels, induces increased intracellular calcium concentrations, and leads to the obstruction of auditory signal transmission[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse models[2]
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Dosage:600 mg/kg
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Administration:ip, once daily for 12 days
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Result:Upregulated the expression of FGF receptors and connexin 43, increased the number of BrdU-positive cells in the spiral ligament.
Chemical Information
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CAS No. 128-46-1
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Masse moléculaire 611.64
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Formule C23H45N7O12
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SMILES
CN[C@H]1[C@@H]([C@H]([C@@H](O[C@@]1(C)O[C@H]2[C@H](O[C@H]([C@@]2(CO)O)C)O[C@@]3(C)[C@@H]([C@H]([C@@H]([C@H]([C@@H]3NC(N)=N)O)NC(N)=N)O)O)CO)O)O
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Synonyms
DHSM
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Marcotti W, et al. The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. J Physiol. 2005 Sep 1;567(Pt 2):505-21. [Content Brief]
[2]. Yamashita H, et al., Cell proliferation in spiral ligament of mouse cochlea damaged by dihydrostreptomycin sulfate. Acta Otolaryngol. 1999;119(3):322-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydrostreptomycin Related Classifications
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