DM-4111
DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.
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- CAS No.: 926035-36-1
- Formule: C26H25ClN2O4
- Masse moléculaire:464.94
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Vasopressin Receptor
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Activité biologique
Description
IC50 & Target
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V2 Receptor |
Chemical Information
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CAS No. 926035-36-1
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Masse moléculaire 464.94
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Formule C26H25ClN2O4
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SMILES
O=C(NC1=CC=C(C(N2CC[C@H](O)[C@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hoshikawa K, et al. Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma. Ann Clin Biochem. 2019 May;56(3):387-396. [Content Brief]
[2]. Hoshikawa K, et al. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients. Basic Clin Pharmacol Toxicol. 2020 Apr;126(4):353-363. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DM-4111 Related Classifications
HY-165423 Related Classifications
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