DW18134
DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function .
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- CAS No.: 2626988-87-0
- Formule: C24H21N5O3
- Masse moléculaire:427.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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IRAK4 11.2 nM (IC50) |
Chemical Information
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CAS No. 2626988-87-0
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Masse moléculaire 427.46
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Formule C24H21N5O3
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SMILES
CC(O1)(C)CC2=C1C=C(C3=CC=NC=C3)C(NC(C4=COC(C5=CC(N)=NC=C5)=N4)=O)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DW18134 Related Classifications
HY-161620 Related Classifications
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