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Cat. No.: HY-N19295

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Echiguanine A

Echiguanine A is a phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC₅₀ of 0.04 μg/mL. Echiguanine A inhibits phosphatidylinositol 4-kinase activity in cell membrane extracts. Echiguanine A is applicable for cancer research.

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CAS No.: 137319-25-6
Formule: C₁₀H₁₃N₇O₂
Masse moléculaire:263.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Echiguanine A Chemical Structure

CAS No.: 137319-25-6

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Description

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Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.03 μg/mL Compound: 1 (echiguanine A)	Inhibition of Phosphatidylinositol 4-kinase of human epidermoid carcinoma A431 cells Inhibition of Phosphatidylinositol 4-kinase of human epidermoid carcinoma A431 cells	10.1016/S0960-894X(97)00122-4

In Vitro

Echiguanine A (Compound 1) (20 min) potently inhibits phosphatidylinositol-4-kinase derived from A431 cell membranes, with an IC₅₀ value of 0.04 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 137319-25-6
Masse moléculaire 263.26
Formule C₁₀H₁₃N₇O₂
SMILES

O=C1N=C(NC2=C1C(C(NCCC(N)=N)=O)=CN2)N
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces sp.
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nishioka H, et al. Isolation and structure determination of novel phosphatidylinositol kinase inhibitors, echiguanines A and B, from Streptomyces sp. J Nat Prod. 1991;54(5):1321-1325. [Content Brief]

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Echiguanine A

Voir tous les produits spécifiques à Isoform PI4K

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Echiguanine A Related Classifications

HY-N19295 Related Classifications