EM-163
Based on 1 Customer Validation
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B).
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- Pureté : 95.0%
- CAS No.: 1206480-93-4
- Formule: C44H60IN5O4
- Masse moléculaire:849.88
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
EM-163 (50-100 μg/mL) can target the TIR domain, binding to the protein of the TIR domain and inhibit the interaction of the TIR-TIR domain [1].
EM-163 (10-500 μM; 30 min) inhibits the production of TNF-α, IFN-γ, IL-2 and IL-1b induced by SEB (200 ng/mL) in human mononuclear cells (MNS) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SEB-induced BALB/c mice model [1]
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Dosage:0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse
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Administration:Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.
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Result:Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.
Delayed mouse death even at high doses of SEB (5 μg).
Chemical Information
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CAS No. 1206480-93-4
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Appearance Solid
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Masse moléculaire 849.88
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Formule C44H60IN5O4
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Color Brown to dark brown
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SMILES
O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C(C3=C[N+](C)=C(C=C3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O.[I-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EM-163 Related Classifications
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