Erbstatin
Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect.
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- CAS No.: 100827-28-9
- Formule: C9H9NO3
- Masse moléculaire:179.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | GI50 |
3 μg/mL
Compound: 66
|
Cytotoxicity against human A431 cells
Cytotoxicity against human A431 cells
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[PMID: 1479375] |
| A-431 | IC50 |
2 μM
Compound: 1 (erbstatin)
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Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells
Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells
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[PMID: 8355247] |
| L1210 | GI50 |
3 μg/mL
Compound: 66
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Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
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[PMID: 1479375] |
Erbstatin does not inhibit the binding of EGF to its receptor but did inhibit the internalization of EGFR complexes and that this compound does not inhibit EGF-stimulated phosphotidylinositol turnover in A431 cells[2].
Erbstatin induces morphological apoptosis and DNA fragmentation in human small cell lung carcinoma (SCLC) cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 100827-28-9
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Masse moléculaire 179.17
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Formule C9H9NO3
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SMILES
O=CN/C=C/C1=CC(O)=CC=C1O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src(ts)NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1585-92. [Content Brief]
[2]. M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4. [Content Brief]
[3]. S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56(21):4978-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Erbstatin Related Classifications
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