country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

DRAP1 - DR1 associated protein 1 Gene

Also Known as NC2-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10589

About DRAP1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,919,426-65,921,563 (from NCBI)

This gene has 9 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 51.3), fat (RPKM 37.1) and 25 other tissues.

Summary

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]

DRAP1 Products (1)

mRNA	Protein	Name
NM_006442.4	NP_006433.2	dr1-associated corepressor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	8670811	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	8670811	GOA
enables RNA polymerase II general transcription initiation factor binding	IDA IDA: Inferred from direct assay	8608938	GOA
enables RNA polymerase II general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	8670811	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	8670811	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8670811	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	8670811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRAP1 Protein Structure

CBFD_NFYB_HMF

0
100
205 a.a.

Protein Preferred Names	Protein Names
dr1-associated corepressor	negative co-factor 2-alpha

DRAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	DRAP1	Q14919	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	DRAP1	Q14919	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	DRAP1	Q14919	GTF2B	Homo sapiens	Q00403	Y2H Prey Pooling	25416956
Intra	DRAP1	Q14919	GTF2B	Homo sapiens	Q00403	Validated Y2H	25416956
Intra	DRAP1	Q14919	NFYB	Homo sapiens	P25208	Validated Y2H	25416956
Intra	DRAP1	Q14919	NFYB	Homo sapiens	P25208	Y2H Array	25416956
Intra	DRAP1	Q14919	NFYB	Homo sapiens	P25208	Y2H Prey Pooling	25416956
Intra	DRAP1	Q14919	TAF9	Homo sapiens	Q16594	Y2H Array	25416956
Intra	DRAP1	Q14919	TAF9	Homo sapiens	Q16594	Validated Y2H	32296183
Intra	DRAP1	Q14919	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	25416956
Intra	DRAP1	Q14919	SDCBP	Homo sapiens	O00560	Validated Y2H	27107012
Intra	DRAP1	Q14919	SDCBP	Homo sapiens	O00560	BFG-2H	27107012
Intra	DRAP1	Q14919	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	DRAP1	Q14919	LMO2	Homo sapiens	P25791	Y2H	21516116
Intra	DRAP1	Q14919	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	DRAP1	Q14919	POLE3	Homo sapiens	Q9NRF9	Y2H Array	25416956
Intra	DRAP1	Q14919	POLE3	Homo sapiens	Q9NRF9	Validated Y2H	25416956
Intra	DRAP1	Q14919	POLE3	Homo sapiens	Q9NRF9	Y2H Pooling	16189514
Intra	DRAP1	Q14919	POLE3	Homo sapiens	Q9NRF9	Validated Y2H	32296183
Intra	DRAP1	Q14919	TAF9B	Homo sapiens	Q9HBM6	Y2H Prey Pooling	25416956
Intra	DRAP1	Q14919	TAF9B	Homo sapiens	Q9HBM6	Validated Y2H	32296183
Intra	DRAP1	Q14919	TAF9B	Homo sapiens	Q9HBM6	Y2H Array	25416956
Intra	DRAP1	Q14919	TAF9B	Homo sapiens	Q9HBM6	Y2H Pooling	16189514
Intra	DRAP1	Q14919	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DRAP1	Q14919	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183
Intra	DRAP1	Q14919	PIK3R3	Homo sapiens	Q92569	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Renpenning Syndrome 1	Renpenning Syndrome Golabi-Ito-Hall Syndrome Mrxs3 Mrxs8 X-Linked Intellectual Disability Due To Pqbp1 Mutations RENS1 Sutherland-Haan X-Linked Mental Retardation Syndrome Shs Mrx55 X-Linked Intellectual Disability, Renpenning Type Sutherland-Haan Syndrome Mental Retardation, X-Linked, Renpenning Type Mental Retardation, X-Linked, With Spastic Diplegia Mental Retardation, X-Linked, Syndromic 3 Mental Retardation, X-Linked, Syndromic 8 Mental Retardation, X-Linked 55 Syndromic X-Linked Mental Retardation 8 X-Linked Mental Retardation Renpenning Type X-Linked Mental Retardation With Spastic Diplegia Sutherland-Haan X-Linked Intellectual Disability Syndrome X-Linked Intellectual Disability With Spastic Diplegia Hamel Cerebropalatocardiac Syndrome Porteous Syndrome X-Linked Intellectual Deficit Due To Pqbp1 Mutations X-Linked Intellectual Deficit, Renpenning Type X-Linked Intellectual Disability, Sutherland-Haan Type Hamel Cerebro-Palato-Cardiac Syndrome Renpenning Syndrome, Type 1
Triple-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03989	DRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DRAP1	VGNC	VGNC:61621
Mus musculus	DRAP1	MGD	MGI:1913806
Rattus norvegicus	DRAP1	RGD	RGD:1308477
Canis familiaris	DRAP1	VGNC	VGNC:103671
Bos taurus	DRAP1	VGNC	VGNC:28203
Macaca mulatta	DRAP1	VGNC	VGNC:71987
Others	DRAP1	NCBI