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PHB2 - prohibitin 2 Gene

Also Known as BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11331

About PHB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,965,327-6,970,753 (from NCBI)

This gene has 20 transcripts (splice variants), 251 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 111.2), duodenum (RPKM 62.9) and 25 other tissues.

Summary

Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022]

PHB2 Products (2)

mRNA	Protein	Name
NM_001144831.2	NP_001138303.1	prohibitin-2 isoform 1
NM_001267700.1	NP_001254629.1	prohibitin-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables amide binding	IPI IPI: Inferred from physical interaction	19116139	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	31522117	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10359819	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	28017329	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	31522117	GOA
enables sphingolipid binding	IDA IDA: Inferred from direct assay	20959514	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in RIG-I signaling pathway	IDA IDA: Inferred from direct assay	31522117	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	31522117	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	24003225	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in mitophagy	IDA IDA: Inferred from direct assay	28017329	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18629613	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10359819	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18629613	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22417827	GOA
NOT involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	24003225	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	23548868	GOA
involved in positive regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	23548868	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	17008324	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18339324	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
NOT involved in regulation of complement activation	IDA IDA: Inferred from direct assay	17070910	GOA
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	20959514	GOA
involved in sister chromatid cohesion	IDA IDA: Inferred from direct assay	23548868	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cell periphery	IDA IDA: Inferred from direct assay	19906925	GOA
located in cell surface	IDA IDA: Inferred from direct assay	22417827	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19116139	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	18339324	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	17008324	GOA
part of mitochondrial prohibitin complex	IDA IDA: Inferred from direct assay	31522117	GOA
part of mitochondrial prohibitin complex	IPI IPI: Inferred from physical interaction	20959514	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19906925	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	21328542	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17008324	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22997079	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21328542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHB2 Protein Structure

Band_7

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
prohibitin-2	B cell receptor associated protein 37

PHB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Y2H Pooling	32814053
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Validated Y2H	32814053
Intra	PHB2	Q99623	PCDHGC3	Homo sapiens	Q9BR81	Y2H Array	32814053
Intra	PHB2	Q99623	ESR1	Homo sapiens	P03372	Pull Down	10359819
Intra	PHB2	Q99623	ESR1	Homo sapiens	P03372	Y2H	10359819

Cross: Cross-species interaction Intra: Intraspecies interaction

PHB2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82103	REA Antibody (YA1848)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P82103A	REA Antibody (YA1848)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Breast Medullary Carcinoma	Medullary Breast Carcinoma Medullary Breast Carcinoma With Lymphoid Stroma Medullary Carcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-114989	Fluorizoline	Inducer	99.77%	Unkown
HY-152093	YL-939	Inhibitor	99.03%	Unkown
HY-117113	JI051	Inhibitor	98.0%	Unkown
HY-124484	JI130	Inhibitor	99.41%	Unkown
HY-162904	BPU17		98.16%	Unkown
HY-RS16807	Phb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179574	AURKA-IN-4	Inhibitor	99.88%	Unkown
HY-RS10408	PHB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23247	Phb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHB2	VGNC	VGNC:44476
Macaca mulatta	PHB2	VGNC	VGNC:100088
Bos taurus	PHB2	VGNC	VGNC:32809
Felis catus	PHB2	VGNC	VGNC:64132
Rattus norvegicus	PHB2	RGD	RGD:620203
Mus musculus	PHB2	MGD	MGI:102520
Others	PHB2	NCBI