PATL1 - PAT1 homolog 1, processing body mRNA decay factor Gene

Also Known as Pat1b; hPat1b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 219988

About PATL1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,636,716-59,669,037 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.

Summary

Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body and cytosol. Colocalizes with CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

PATL1 Products (1)

mRNA Protein Name
NM_152716.3 NP_689929.2 protein PAT1 homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables RNA binding IDA
IDA: Inferred from direct assay
20543818 GOA
enables poly(G) binding IDA
IDA: Inferred from direct assay
20826699 GOA
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
20826699 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20543818 GOA
Biological Process GO Annotation Evidence Références Source
involved in P-body assembly IDA
IDA: Inferred from direct assay
20584987 GOA
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: Inferred from direct assay
20584987 GOA
Cellular Component GO Annotation Evidence Références Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
20584987 GOA
located in P-body IDA
IDA: Inferred from direct assay
20543818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PATL1 Protein Structure

PAT1

PAT1: Topoisomerase II-associated protein PAT1 (15 - 439)

PAT1

PAT1: Topoisomerase II-associated protein PAT1 (460 - 717)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

protein PAT1 homolog 1

  • PAT1-like protein 1

PATL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
PATL1 Q86TB9 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
PATL1 Q86TB9 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
PATL1 Q86TB9 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
PATL1 Q86TB9 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
PATL1 Q86TB9 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Validated Y2H
32296183
Intra
PATL1 Q86TB9 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
PATL1 Q86TB9 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Validated Y2H
32296183
Intra
PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Y2H Array
32296183
Intra
PATL1 Q86TB9 LSM2 Homo sapiens Q9Y333
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 LSM1 Homo sapiens O15116
Y2H Array
32296183
Intra
PATL1 Q86TB9 LSM1 Homo sapiens O15116
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 LSM1 Homo sapiens O15116
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra
PATL1 Q86TB9 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra
PATL1 Q86TB9 DDX6 Homo sapiens P26196
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 LSM6 Homo sapiens P62312
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 LSM6 Homo sapiens P62312
Y2H Array
32296183
Intra
PATL1 Q86TB9 DCP1A Homo sapiens Q9NPI6
Anti Tag CoIP
20584987
Intra
PATL1 Q86TB9 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PATL1 Q86TB9 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra
PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
PATL1 Q86TB9 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Intra
PATL1 Q86TB9 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
20584987
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome 7

  • HPS7

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 7

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Retinitis Pigmentosa 13

  • RP13

  • Retinitis Pigmentosa-13

  • Retinitis Pigmentosa, Type 13
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10084 PATL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PATL1 VGNC VGNC:44272
Macaca mulatta PATL1 VGNC VGNC:75684
Mus musculus PATL1 MGD MGI:2147679
Felis catus PATL1 VGNC VGNC:64049
Bos taurus PATL1 VGNC VGNC:32593
Rattus norvegicus PATL1 RGD RGD:1305514
Others PATL1 NCBI