GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

Also Known as ARSA1; ASNA1; TRC40; ARSA-I; ASNA-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 439

About GET3

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,737,106-12,748,323 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 39.3), thyroid (RPKM 34.9) and 25 other tissues.

Summary

This gene represents the human homolog of the Bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

GET3 Products (3)

mRNA	Protein	Name
NM_001371488.1	NP_001358417.1	ATPase GET3
NM_001371489.1	NP_001358418.1	ATPase GET3
NM_004317.4	NP_004308.2	ATPase GET3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables membrane insertase activity	IDA IDA: Inferred from direct assay	23610396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	25535373	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	23041287	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of GET complex	IDA IDA: Inferred from direct assay	32910895	GOA
part of GET complex	IPI IPI: Inferred from physical interaction	23041287	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	32910895	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GET3 Protein Structure

ArsA_ATPase

0
100
200
300
348 a.a.

Protein Preferred Names	Protein Names
ATPase GET3	arsA arsenite transporter, ATP-binding, homolog 1

GET3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	GET3	O43681	PDIA6	Homo sapiens	Q15084	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PDIA6	Homo sapiens	Q15084	Validated Y2H	32296183
Intra	GET3	O43681	PDIA6	Homo sapiens	Q15084	Y2H Array	32296183
Intra	GET3	O43681	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	GET3	O43681	TMX1	Homo sapiens	Q9H3N1	Validated Y2H	32296183
Intra	GET3	O43681	TMX1	Homo sapiens	Q9H3N1	Y2H Prey Pooling	32296183
Intra	GET3	O43681	TMX1	Homo sapiens	Q9H3N1	Y2H Array	32296183
Intra	GET3	O43681	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	GET3	O43681	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	GET3	O43681	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	GET3	O43681	KCNE4	Homo sapiens	Q8WWG9	Validated Y2H	32296183
Intra	GET3	O43681	KCNE4	Homo sapiens	Q8WWG9	Y2H Prey Pooling	32296183
Intra	GET3	O43681	KCNE4	Homo sapiens	Q8WWG9	Y2H Array	32296183
Intra	GET3	O43681	FAM163A	Homo sapiens	Q96GL9	Y2H Prey Pooling	32296183
Intra	GET3	O43681	FAM163A	Homo sapiens	Q96GL9	Validated Y2H	32296183
Intra	GET3	O43681	FAM163A	Homo sapiens	Q96GL9	Y2H Array	32296183
Intra	GET3	O43681	VWC2	Homo sapiens	Q2TAL6	Validated Y2H	32296183
Intra	GET3	O43681	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	GET3	O43681	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	GET3	O43681	KCNE5	Homo sapiens	Q9UJ90	Y2H Array	32296183
Intra	GET3	O43681	KCNE5	Homo sapiens	Q9UJ90	Y2H Prey Pooling	32296183
Intra	GET3	O43681	KCNE5	Homo sapiens	Q9UJ90	Validated Y2H	32296183
Intra	GET3	O43681	EMSY	Homo sapiens	Q7Z589-5	Validated Y2H	32296183
Intra	GET3	O43681	EMSY	Homo sapiens	Q7Z589-5	Y2H Array	32296183
Intra	GET3	O43681	EMSY	Homo sapiens	Q7Z589-5	Y2H Prey Pooling	32296183
Intra	GET3	O43681	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	GET3	O43681	LDLRAD4	Homo sapiens	O15165-2	Y2H Array	32296183
Intra	GET3	O43681	LDLRAD4	Homo sapiens	O15165-2	Y2H Prey Pooling	32296183
Intra	GET3	O43681	TMEM154	Homo sapiens	Q6P9G4	Y2H Prey Pooling	32296183
Intra	GET3	O43681	TMEM154	Homo sapiens	Q6P9G4	Validated Y2H	32296183
Intra	GET3	O43681	TMEM154	Homo sapiens	Q6P9G4	Y2H Array	32296183
Intra	GET3	O43681	PRB3	Homo sapiens	Q04118	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PRB3	Homo sapiens	Q04118	Validated Y2H	32296183
Intra	GET3	O43681	PRB3	Homo sapiens	Q04118	Y2H Array	32296183
Intra	GET3	O43681	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	GET3	O43681	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	GET3	O43681	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	GET3	O43681	CAMLG	Homo sapiens	P49069	Y2H Prey Pooling	32296183
Intra	GET3	O43681	CAMLG	Homo sapiens	P49069	Complementation	32296183
Intra	GET3	O43681	CAMLG	Homo sapiens	P49069	Anti Tag CoIP	33961781
Intra	GET3	O43681	CAMLG	Homo sapiens	P49069	Y2H Array	32296183
Intra	GET3	O43681	CAMLG	Homo sapiens	P49069	Validated Y2H	32296183
Intra	GET3	O43681	SMIM19	Homo sapiens	Q96E16	Y2H Array	32296183
Intra	GET3	O43681	SMIM19	Homo sapiens	Q96E16	Validated Y2H	32296183
Intra	GET3	O43681	SMIM19	Homo sapiens	Q96E16	Y2H Prey Pooling	32296183
Intra	GET3	O43681	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Prey Pooling	32296183
Intra	GET3	O43681	SYPL2	Homo sapiens	Q5VXT5-2	Validated Y2H	32296183
Intra	GET3	O43681	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Array	32296183
Intra	GET3	O43681	RHEX	Homo sapiens	Q6ZWK4	Y2H Prey Pooling	32296183
Intra	GET3	O43681	RHEX	Homo sapiens	Q6ZWK4	Y2H Array	32296183
Intra	GET3	O43681	RHEX	Homo sapiens	Q6ZWK4	Validated Y2H	32296183
Intra	GET3	O43681	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	GET3	O43681	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	GET3	O43681	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GET3	O43681	CSPG5	Homo sapiens	O95196-2	Validated Y2H	32296183
Intra	GET3	O43681	CSPG5	Homo sapiens	O95196-2	Y2H Prey Pooling	32296183
Intra	GET3	O43681	CSPG5	Homo sapiens	O95196-2	Y2H Array	32296183
Intra	GET3	O43681	ASPH	Homo sapiens	Q12797	Y2H Prey Pooling	25416956
Intra	GET3	O43681	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	GET3	O43681	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	GET3	O43681	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	GET3	O43681	CREB3L4	Homo sapiens	Q8TEY5	Validated Y2H	32296183
Intra	GET3	O43681	CREB3L4	Homo sapiens	Q8TEY5	Y2H Array	32296183
Intra	GET3	O43681	CREB3L4	Homo sapiens	Q8TEY5	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PEX14	Homo sapiens	O75381	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PEX14	Homo sapiens	O75381	Validated Y2H	32296183
Intra	GET3	O43681	PEX14	Homo sapiens	O75381	Y2H Array	32296183
Cross	GET3	O43681	yscD	Yersinia pestis	Q56975	Y2H Array	21911467
Intra	GET3	O43681	GET4	Homo sapiens	Q7L5D6	Y2H Array	32296183
Intra	GET3	O43681	GET4	Homo sapiens	Q7L5D6	Validated Y2H	32296183
Intra	GET3	O43681	GET4	Homo sapiens	Q7L5D6	Y2H Prey Pooling	32296183
Intra	GET3	O43681	GET4	Homo sapiens	Q7L5D6	Y2H	21516116
Intra	GET3	O43681	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	GET3	O43681	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	GET3	O43681	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	GET3	O43681	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	GET3	O43681	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	GET3	O43681	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	GET3	O43681	SPP1	Homo sapiens	P10451	Y2H Prey Pooling	32296183
Intra	GET3	O43681	SPP1	Homo sapiens	P10451	Validated Y2H	32296183
Intra	GET3	O43681	SPP1	Homo sapiens	P10451	Y2H Array	32296183
Intra	GET3	O43681	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	GET3	O43681	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	GET3	O43681	PRR4	Homo sapiens	Q16378	Y2H Array	32296183
Intra	GET3	O43681	PRR4	Homo sapiens	Q16378	Y2H Prey Pooling	32296183
Intra	GET3	O43681	PRR4	Homo sapiens	Q16378	Validated Y2H	32296183
Intra	GET3	O43681	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	GET3	O43681	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	GET3	O43681	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	GET3	O43681	GPX7	Homo sapiens	Q96SL4	Validated Y2H	32296183
Intra	GET3	O43681	GPX7	Homo sapiens	Q96SL4	Y2H Array	32296183
Intra	GET3	O43681	GPX7	Homo sapiens	Q96SL4	Y2H Array	25416956
Intra	GET3	O43681	GPX7	Homo sapiens	Q96SL4	Y2H Prey Pooling	32296183
Intra	GET3	O43681	WFDC3	Homo sapiens	Q8IUB2	Validated Y2H	32296183
Intra	GET3	O43681	WFDC3	Homo sapiens	Q8IUB2	Y2H Prey Pooling	32296183
Intra	GET3	O43681	WFDC3	Homo sapiens	Q8IUB2	Y2H Array	32296183
Intra	GET3	O43681	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183
Intra	GET3	O43681	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183
Intra	GET3	O43681	IGFBP6	Homo sapiens	P24592	Validated Y2H	32296183
Intra	GET3	O43681	RCN1	Homo sapiens	Q15293	Y2H Array	32296183
Intra	GET3	O43681	RCN1	Homo sapiens	Q15293	Y2H Prey Pooling	32296183
Intra	GET3	O43681	RCN1	Homo sapiens	Q15293	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Breast Adenoma	Ademoma - Breast
Nephronophthisis 1	NPHP1 Nephronophthisis, Familial Juvenile Nph1 Nephronophthisis 1, Juvenile Juvenile Nephronophthisis 1 Familial Juvenile Nephronophthisis 1 Nephronophthisis, Type 1
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05374	GET3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GET3	MGD	MGI:1928379
Rattus norvegicus	GET3	RGD	RGD:1307906
Felis catus	GET3	VGNC	VGNC:80262
Macaca mulatta	GET3	VGNC	VGNC:80258
Bos taurus	GET3	VGNC	VGNC:96696
Canis familiaris	GET3	VGNC	VGNC:102781
Others	GET3	NCBI