CDK16 - cyclin dependent kinase 16 Gene

Also Known as PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5127

About CDK16

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,218,303-47,229,997 (from NCBI)

This gene has 22 transcripts (splice variants), 174 orthologues, 26 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

CDK16 Products (15)

mRNA Protein Name
XM_047442152.1 XP_047298108.1 cyclin-dependent kinase 16 isoform X5
NM_006201.5 NP_006192.1 cyclin-dependent kinase 16 isoform 1
XM_011543922.2 XP_011542224.1 cyclin-dependent kinase 16 isoform X4
XM_011543926.2 XP_011542228.1 cyclin-dependent kinase 16 isoform X7
NM_001170460.2 NP_001163931.1 cyclin-dependent kinase 16 isoform 3
NM_033018.4 NP_148978.2 cyclin-dependent kinase 16 isoform 2
XM_011543920.4 XP_011542222.1 cyclin-dependent kinase 16 isoform X1
XM_011543923.3 XP_011542225.1 cyclin-dependent kinase 16 isoform X6
XM_011543925.3 XP_011542227.1 cyclin-dependent kinase 16 isoform X7
NM_033019.1
XM_047442153.1 XP_047298109.1 cyclin-dependent kinase 16 isoform X8
XM_017029569.2 XP_016885058.1 cyclin-dependent kinase 16 isoform X3
XM_011543924.3 XP_011542226.1 cyclin-dependent kinase 16 isoform X7
XM_047442154.1 XP_047298110.1 cyclin-dependent kinase 16 isoform X9
XM_011543921.2 XP_011542223.1 cyclin-dependent kinase 16 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12154078 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22184064 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
32098961 GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22798068 GOA
Cellular Component GO Annotation Evidence Références Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
19524571 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22798068 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
22184064 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19524571 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK16 Protein Structure

Pkinase

Pkinase: Protein kinase domain (166 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 16

  • PCTAIRE-motif protein kinase 1

  • cell division protein kinase 16

  • serine/threonine-protein kinase PCTAIRE-1

  • testis secretory sperm-binding protein Li 224n

CDK16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
25852190
Intra
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
26496610
Intra
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Anti Tag CoIP
33961781
Intra
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Y2H
22184064
Intra
CDK16 Q00536 CCNYL1 Homo sapiens Q8N7R7
Pull Down
32707033
Intra
CDK16 Q00536 ZBTB14 Homo sapiens O43829
Validated Y2H
25416956
Intra
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Anti Tag CoIP
33961781
Intra
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Y2H
22184064
Intra
CDK16 Q00536 CCNY Homo sapiens Q8ND76
Pull Down
32707033
Intra
CDK16 Q00536 CCNY Homo sapiens Q8ND76-1
Protein Kinase Assay
22184064
Intra
CDK16 Q00536 CCNY Homo sapiens Q8ND76-1
Anti Tag CoIP
22184064
Intra
CDK16 Q00536 YWHAZ Homo sapiens P63104
Anti Tag CoIP
25852190
Intra
CDK16 Q00536 YWHAZ Homo sapiens P63104
Pull Down
12154078
Intra
CDK16 Q00536 YWHAE Homo sapiens P62258
Anti Tag CoIP
25852190
Intra
CDK16 Q00536 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
CDK16 Q00536 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
CDK16 Q00536 CDK17 Homo sapiens Q00537
Anti Tag CoIP
33961781
Intra
CDK16 Q00536 CDK17 Homo sapiens Q00537
Anti Tag CoIP
28514442
Intra
CDK16 Q00536 SEC23A Homo sapiens Q15436
Pull Down
16091426
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK16 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P76536 PCTAIRE1 Protein, Human (sf9, GST) Q00536-1 (M1-F496) ≥ 80%, as determined by reducing SDS-PAGE.

CDK16 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P80612 CDK16 Antibody (YA515) WB Human
HY-P80612A CDK16 Antibody (YA515)(PBS only) WB Human

Related Diseases

Diseases Alias
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-148063 DB0614 99.92% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-160213 JA397 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDK16 RGD RGD:620584
Felis catus CDK16 VGNC VGNC:68735
Mus musculus CDK16 MGD MGI:97516
Bos taurus CDK16 VGNC VGNC:27119
Macaca mulatta CDK16 VGNC VGNC:71160
Canis familiaris CDK16 VGNC VGNC:39048
Others CDK16 NCBI