CD244 - CD244 molecule Gene

Also Known as 2B4; NAIL; Nmrk; NKR2B4; SLAMF4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51744

About CD244

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,830,160-160,862,887 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 7.3), bone marrow (RPKM 3.3) and 12 other tissues.

Summary

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

CD244 Products (3)

mRNA Protein Name
NM_001166663.2 NP_001160135.1 natural killer cell receptor 2B4 isoform 2 precursor
NM_001166664.2 NP_001160136.1 natural killer cell receptor 2B4 isoform 3 precursor
NM_016382.4 NP_057466.1 natural killer cell receptor 2B4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables MHC class I protein binding IDA
IDA: Inferred from direct assay
20164429 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11489943 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
27249817 GOA
Biological Process GO Annotation Evidence Références Source
involved in natural killer cell activation IDA
IDA: Inferred from direct assay
27249817 GOA
involved in natural killer cell activation involved in immune response IDA
IDA: Inferred from direct assay
11714776 GOA
involved in positive regulation of granzyme B production IDA
IDA: Inferred from direct assay
11714776 GOA
involved in positive regulation of inositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
8376943 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
8376943 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11714776 GOA
Cellular Component GO Annotation Evidence Références Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17213291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD244 Protein Structure

Receptor_2B4

Receptor_2B4: Natural killer cell receptor 2B4 (22 - 127)

Ig_2

Ig_2: Immunoglobulin domain (137 - 215)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

natural killer cell receptor 2B4

  • CD244 molecule, natural killer cell receptor 2B4

CD244 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CD244 Q9BZW8 INPP5D Homo sapiens Q92835
Pull Down
24642916
Intra
CD244 Q9BZW8 INPP5D Homo sapiens Q92835
SPR
26221972
Intra
CD244 Q9BZW8 INPP5D Homo sapiens Q92835
SPR
24642916
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880-1
Anti Tag CoIP
16983070
Intra
CD244 Q9BZW8 PTPN11 Homo sapiens Q06124
SPR
24642916
Intra
CD244 Q9BZW8 PTPN11 Homo sapiens Q06124
Pull Down
24642916
Intra
CD244 Q9BZW8 SH2D1B Homo sapiens O14796
Pull Down
24642916
Intra
CD244 Q9BZW8 SH2D1B Homo sapiens O14796
SPR
24642916
Intra
CD244 Q9BZW8 SH2D1B Homo sapiens O14796
Anti Bait CoIP
23346089
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880
SPR
24642916
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880
Pull Down
24642916
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880
Anti Bait CoIP
11489943
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880
Anti Bait CoIP
23346089
Intra
CD244 Q9BZW8 SH2D1A Homo sapiens O60880
SPR
26221972
Intra
CD244 Q9BZW8 B2M Homo sapiens P61769
Anti Bait CoIP
20164429
Intra
CD244 Q9BZW8 CD48 Homo sapiens P09326
FACS
15153464
Intra
CD244 Q9BZW8 CD48 Homo sapiens P09326
FACS
16002700
Intra
CD244 Q9BZW8 PTPN6 Homo sapiens P29350
Pull Down
24642916
Intra
CD244 Q9BZW8 PTPN6 Homo sapiens P29350
Anti Bait CoIP
11489943
Intra
CD244 Q9BZW8 PLCG1 Homo sapiens P19174
SPR
24642916
Intra
CD244 Q9BZW8 PLCG1 Homo sapiens P19174
Pull Down
24642916
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD244 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P72745 2B4/CD244 Protein, Human (HEK293, His) Q9BZW8-2 (C22-R221) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78052 2B4/CD244 Protein, Human (Biotinylated, HEK293, His-Avi) Q9BZW8-2 (C22-R221) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78366 2B4/CD244 Protein, Human (HEK293, Fc) Q9BZW8-2 (C22-R221) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78912 2B4/CD244 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q9BZW8-2 (C22-R221) ≥ 95%, as determined by reducing SDS-PAGE.

CD244 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81637 2B4 Antibody (YA1382) ICC/IF, FC, ELISA Human
HY-P84779 2B4 Antibody (YA4476) ICC/IF, FC, ELISA Human
HY-P84779A 2B4 Antibody (YA4476)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Mycobacterium Tuberculosis 1

  • Tuberculosis

  • Tuberculoma

  • Tuberculosis, Susceptibility To

  • Mycobacterium Tuberculosis, Susceptibility To, 1

  • Mtbs1

  • TB
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Lymphoproliferative Syndrome

  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To
Lymphoproliferative Syndrome, X-Linked, 1

  • Lymphomatoid Papulosis

  • Duncan Disease

  • Purtilo Syndrome

  • X-Linked Lymphoproliferative Syndrome

  • Xlp

  • X-Linked Lymphoproliferative Disease

  • XLP1

  • Lyp

  • Lymphoproliferative Disease, X-Linked

  • Xlpd

  • X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

  • Ebv Infection, Severe, Susceptibility To

  • Ebvs

  • Immunodeficiency 5

  • Imd5

  • X-Linked Lymphoproliferative Syndrome 1

  • Epstein-Barr Virus Infection, Familial Fatal

  • Ebv Infection, Severe

  • Infectious Mononucleosis, Severe

  • Infectious Mononucleosis, Severe, Susceptibility To

  • Immunodeficiency, X-Linked Progressive Combined Variable

  • Epstein Barr Virus Infection, Familial Fatal

  • X-Linked Progressive Combined Variable Immunodeficiency 5

  • Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

  • Familial Fatal Epstein-Barr Infection

  • Severe Susceptibility To Ebv Infection

  • Severe Susceptibility To Infectious Mononucleosis

  • Sap Deficiency

  • Sh2d1a/Slam-Associated Protein Deficiency

  • X-Linked Lymphoproliferative Syndrome Type 1

  • X-Linked Progressive Combined Variable Immunodeficiency

  • Lymphoproliferative Syndrome, X-Linked

  • Sap

  • X-Linked Lymphoproliferative Disorder
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02213 CD244 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24862 Cd244 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990266 Anti-Mouse CD48 Antibody (HM48-1) Inhibitor 97.738% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CD244 MGD MGI:109294
Bos taurus CD244 VGNC VGNC:27015
Rattus norvegicus CD244 RGD RGD:68400
Canis familiaris CD244 VGNC VGNC:53117
Macaca mulatta CD244 VGNC VGNC:70821
Felis catus CD244 VGNC VGNC:60599
Others CD244 NCBI