HAUS6 - HAUS augmin like complex subunit 6 Gene

Also Known as Dgt6; FAM29A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54801

About HAUS6

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,053,141-19,102,904 (from NCBI)

This gene has 3 transcripts (splice variants) and 201 orthologues. Broad expression in testis (RPKM 9.5), lymph node (RPKM 4.7) and 24 other tissues.

Summary

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

HAUS6 Products (2)

mRNA	Protein	Name
NM_001270890.2	NP_001257819.1	HAUS augmin-like complex subunit 6 isoform 2
NM_017645.5	NP_060115.3	HAUS augmin-like complex subunit 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS6 Protein Structure

HAUS6_N

0
200
400
600
800
955 a.a.

Protein Preferred Names	Protein Names
HAUS augmin-like complex subunit 6	dim gamma-tubulin homolog

HAUS6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	HAUS6	Q7Z4H7	HAUS1	Homo sapiens	Q96CS2	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	NEDD1	Homo sapiens	Q8NHV4	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS8	Homo sapiens	Q9BT25	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS8	Homo sapiens	Q9BT25	Y2H	19369198
Intra	HAUS6	Q7Z4H7	HAUS8	Homo sapiens	Q9BT25	TAP	20360068
Intra	HAUS6	Q7Z4H7	HAUS4	Homo sapiens	Q9H6D7	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS3	Homo sapiens	Q68CZ6	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS3	Homo sapiens	Q68CZ6	TAP	20360068
Intra	HAUS6	Q7Z4H7	HAUS5	Homo sapiens	O94927	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS5	Homo sapiens	O94927	TAP	20360068
Intra	HAUS6	Q7Z4H7	HAUS7	Homo sapiens	Q99871	Anti Tag CoIP	19369198
Intra	HAUS6	Q7Z4H7	HAUS7	Homo sapiens	Q99871	TAP	20360068
Intra	HAUS6	Q7Z4H7	HAUS2	Homo sapiens	Q9NVX0	Anti Tag CoIP	19369198

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 30	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency IMD30 Il12rb1 Deficiency Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency Msmd Due To Complete Il12rb1 Deficiency Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency Il-12râ1 Deficiency Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency Immunodeficiency, Type 30
Noonan Syndrome 2	NS2 Noonan Syndrome, Autosomal Recessive Noonan Syndrome 2, Autosomal Recessive Noonan Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06018	HAUS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HAUS6	VGNC	VGNC:41606
Bos taurus	HAUS6	VGNC	VGNC:29761
Felis catus	HAUS6	VGNC	VGNC:62758
Mus musculus	HAUS6	MGD	MGI:1923389
Macaca mulatta	HAUS6	VGNC	VGNC:73237
Others	HAUS6	NCBI