HO 221
HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia.
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- CAS No.: 105128-93-6
- Formule: C18H11BrClN5O5
- Masse moléculaire:492.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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DNA Polymerase |
Chemical Information
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CAS No. 105128-93-6
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Masse moléculaire 492.67
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Formule C18H11BrClN5O5
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SMILES
ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nakajima T, et al. Antitumor activity on murine tumors of a novel antitumor benzoylphenylurea derivative, HO-221. Cancer Chemother Pharmacol. 1991;28(5):351-6. [Content Brief]
[2]. Nakajima T, et al. Mechanism of tumor cell killing by HO-221, a novel antitumor compound. Cancer Chemother Pharmacol. 1990;27(3):199-204. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HO 221 Related Classifications
HY-106787 Related Classifications
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