JDS364
JDS364 is a blood-brain barrier-permeable human acetylcholinesterase (hAChE) reactivator with an IC50 of 8.6 μM. JDS364 achieves rapid systemic exposure in mice and acts as a protective agent when used in combination with Atropine (HY-B1205). JDS364 can be used in studies on organophosphate nerve agent poisoning and organophosphate pesticide poisoning.
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- CAS No.: 2072857-15-7
- Formule: C19H20N4O2
- Masse moléculaire:336.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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hAChE 8.6 μM (IC50) |
JDS364 demonstrates broad-spectrum, high-efficiency reactivation of hAChE inhibited by nerve agent surrogates and paraoxon, with exceptional efficacy against tabun surrogate-inhibited hAChE[1].
JDS364 (50 μM) exhibits high permeability across a validated human in vitro BBB model without causing cytotoxicity or barrier disruption, confirming its potential for CNS penetration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Tmax | MRT |
|---|---|---|---|---|
| Mice[1] | 100 μmol/Kg | i.p. | 4.5 min | 33.1 min |
JDS364 (100 μmol/kg; i.p.; single dose) exhibits rapid and efficient functional bioavailability in mouse blood, reaching peak reactivation capacity within 5 minutes of intraperitoneal administration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (male, 9 weeks old, 35-45 g)[1]
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Dosage:100 μmol/kg (monotherapy); 100 μmol/kg + 10 mg/kg atropine (combination therapy)
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Administration:i.p.; single dose; 1 minute post-agent challenge
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Result:Achieved a protective index (PI) of 2.6 against paraoxon, 1.3 against NIMP, and 1.5 against NEMP when administered alone.
Exhibited a PI of 6.7 against paraoxon, 2.7 against NIMP, and 3.7 against NEMP when combined with atropine.
Had a median lethal dose (LD50) of 364 μmol/kg via intraperitoneal administration.
Chemical Information
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CAS No. 2072857-15-7
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Masse moléculaire 336.39
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Formule C19H20N4O2
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SMILES
OC1=CC=C(CCCCNC2=CC=NC3=CC=CC=C23)N=C1/C=N/O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JDS364 Related Classifications
HY-184279 Related Classifications
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