KARS-IN-1
KARS-IN-1 (152) is a AKR1C3 dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. KARS-IN-1 shows anti-proliferative activity in H460 (NRF2 pathway mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild type cell line with low AKR1C3 expression), with AC50 values ??of 21 nM and 16 nM, respectively. KARS-IN-1 can be used for the study of non-small cell lung cancer (NSCLC).
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- CAS No.: 2579083-99-9
- Formule: C21H23F2N3O2
- Masse moléculaire:387.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 2579083-99-9
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Masse moléculaire 387.42
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Formule C21H23F2N3O2
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SMILES
FC(C=C1)=CC=C1CNC(N(CC2)CCC32C[C@@H](O)C4=CC(F)=CC=C4N3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KARS-IN-1 Related Classifications
HY-180562 Related Classifications
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