KF20274
KF20274 is an orally active adenosine A1 receptor antagonist. KF20274 increases the fecal pellet output in rats, and does not affect small intestinal propulsion or gastric emptying at defecation-increasing doses. KF20274 does not induce diarrhea at defecation-increasing doses. KF20274 can be used for the research of constipation.
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- CAS No.: 143394-68-7
- Formule: C21H29N5O
- Masse moléculaire:367.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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A1AR |
KF20274 (0.01-3 mg/kg; p.o.) does not alter small intestinal propulsion, gastric emptying in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 150-250 g)[1]
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Dosage:0.0003, 0.001, 0.003, 0.01, 0.03 mg/kg
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Administration:p.o.
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Result:Increased fecal wet weight and dry weight.
Maintained fecal water content at 51-55%.
Resulted in 0/10 incidence of diarrhea across all tested doses.
Chemical Information
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CAS No. 143394-68-7
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Masse moléculaire 367.49
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Formule C21H29N5O
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SMILES
CCCN1C2=C(C3=N[C@H](CC)CN3C1=O)NC(C45C6CC(CC(C6)C5)C4)=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF20274 Related Classifications
HY-182340 Related Classifications
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