L759633
Based on 1 Customer Validation
L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production.
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- Pureté : 99.9%
- CAS No.: 174627-50-0
- Formule: C26H40O2
- Masse moléculaire:384.59
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Stockage:
Solution, -20°C, 2 years
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CB2 6.4 nM (Ki) |
CB1 1043 nM (Ki) |
In Vitro
L759633 (0.1-1000 nM) inhibits Forskolin-stimulated cyclic AMP production in CB2-transfected cells, with an EC50 of 8.1 nM[1].
L759633 inhibits Forskolin-stimulated cyclic AMP production by 48% at the concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 174627-50-0
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Appearance Liquid
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Masse moléculaire 384.59
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Formule C26H40O2
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Color Colorless to light yellow
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SMILES
COC1=C2[C@@]3([H])[C@](CC=C(C)C3)([H])C(C)(C)OC2=CC(C(C)(C)CCCCCC)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Solution, -20°C, 2 years
Pureté et documentation
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Fiche technique (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Ross RA, et, al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. [Content Brief]
[2]. Dhopeshwarkar A, et, al. Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L759633 Related Classifications
HY-110040 Related Classifications
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