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Luspatercept

(Synonyms: ACE-536; luspatercept–aamt)
5 Cited Publications
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Based on 5 publication(s) in Google Scholar

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.

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  • Pureté: 98.92%
  • CAS No.: 1373715-00-4
  • Masse moléculaire:75.71 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Luspatercept
  • Experimental Validation Results for Luspatercept
  • Experimental Validation Results for Luspatercept
  • Experimental Validation Results for Luspatercept
  • Luspatercept Chemical Structure
    Luspatercept Chemical Structure
CAS No.: 1373715-00-4
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Assay Types
  • 1/16

    [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2-IGHG1 Fc (Fragment constant)

  • 1/16

    Immobilized HY-P72632 GDF-8 Protein, Human/Mouse/Rat (HEK293) can bind Luspatercept. The EC50 for this effect is 74.63 ng/mL.

  • 1/16

    Immobilized HY-P70222Y GDF-11/BMP-11 Protein, Human (HEK293, solution) can bind Luspatercept. The EC50 for this effect is 99.57 ng/mL.

  • 1/16

    Immobilized Recombinant Anti-ACVR2B Antibody can bind Luspatercept. The EC50 for this effect is 3.08 ng/mL.

  • Luspatercept Chemical Structure
    1/16
  • Luspatercept
  • Immobilized HY-P72632 GDF-8 Protein, Human/Mouse/Rat (HEK293) can bind Luspatercept. The EC50 for this effect is 74.63 ng/mL.
  • Immobilized HY-P70222Y GDF-11/BMP-11 Protein, Human (HEK293, solution) can bind Luspatercept. The EC50 for this effect is 99.57 ng/mL.
  • Immobilized Recombinant Anti-ACVR2B Antibody can bind Luspatercept. The EC50 for this effect is 3.08 ng/mL.