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Cat. No.: HY-130161

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m-PEG4-Br

Name: m-PEG4-Br
Brand: MedChemExpress
SKU: HY-130161
Price: 32.00 USD
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m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

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Pureté: 96.34%
CAS No.: 110429-45-3
Formule: C₉H₁₉BrO₄
Masse moléculaire:271.15

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

m-PEG4-Br Chemical Structure

CAS No.: 110429-45-3

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- IC₅₀ & Target
- In Vitro
Chemical Information
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Description

m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency^[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

IC₅₀ & Target^[1]

Cleavable Linker

PEGs

Voir tous les produits spécifiques à Isoform ADC Linkers :

Voir tous les produits spécifiques à Isoform PROTAC Linkers :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 110429-45-3
Appearance Liquid (Density: 1.256 g/cm³)
Masse moléculaire 271.15
Formule C₉H₁₉BrO₄
Color Colorless to light yellow
SMILES

COCCOCCOCCOCCBr
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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m-PEG4-Br

Methyl-PEG3-bromide

m-PEG7-Br

Bromo-PEG2-bromide

m-PEG6-Br

m-PEG2-Br

m-PEG5-Br

m-PEG8-Br

m-PEG9-Br

m-PEG12-Br

Bis(2-bromoethyl) ether

N-Boc-PEG2-bromide

Br-PEG4-OH

Voir tous les produits spécifiques à Isoform ADC Linkers

Voir tous les produits spécifiques à Isoform PROTAC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

m-PEG4-Br

Methyl-PEG3-bromide

m-PEG7-Br

Bromo-PEG2-bromide

m-PEG6-Br

m-PEG2-Br

m-PEG5-Br

m-PEG8-Br

m-PEG9-Br

m-PEG12-Br

Bis(2-bromoethyl) ether

N-Boc-PEG2-bromide

Br-PEG4-OH

Voir tous les produits spécifiques à Isoform ADC Linkers

Voir tous les produits spécifiques à Isoform PROTAC Linkers

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

m-PEG4-Br Related Classifications

HY-130161 Related Classifications

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