MIH-36
MIH-36 is a VEGFR-2 modulator and anticancer agent. MIH-36 decreases VEGFR-2 surface expression in cells while upregulating VEGFR-2 mRNA. MIH-36 induces Apoptosis. MIH-36 exhibits selective anticancer activity against luminal and triple-negative breast cancer. MIH-36 can be used for research on breast cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C21H13F6N5O4S
- Masse moléculaire:545.41
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform VEGFR
More
Activité biologique
Description
IC50 & Target
[1]|
VEGFR2 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
18.9 μM
|
Antiproliferative activity against human breast cancer MDA-MB-231 cells assessed as viability reduction incubated 48 hrs by MTT assay.
Antiproliferative activity against human breast cancer MDA-MB-231 cells assessed as viability reduction incubated 48 hrs by MTT assay.
|
42759396 |
| MCF7 | IC50 |
13.74 μM
|
Antiproliferative activity against human breast cancer MCF-7 cells assessed as viability reduction incubated 48 hrs by MTT assay.
Antiproliferative activity against human breast cancer MCF-7 cells assessed as viability reduction incubated 48 hrs by MTT assay.
|
42759396 |
| L929 | IC50 |
49.40 μM
|
Cytotoxicity against mouse L929 fibroblasts assessed as viability reduction incubated 48 hrs by MTT assay.
Cytotoxicity against mouse L929 fibroblasts assessed as viability reduction incubated 48 hrs by MTT assay.
|
42759396 |
In Vitro
MIH-36 (48 h) inhibited scratch wound closure in MCF-7 cells compared with the control[1].
MIH-36 (48 h) inhibited scratch wound closure in MDA-MB-231 compared with the control[1].
MIH-36 (48 h) reduced the percentage of VEGFR-2 surface-positive cells in MDA-MB-231 (80.4%) and MCF-7 (32.9%) and altered the MFI, indicating modulation of surface VEGFR-2[1].
MIH-36 (48 h) upregulates VEGFR-2 mRNA in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7, MDA-MB-231, and L929 cells
-
Concentration:400, 200, 100, 50, 25, and 12.5 μM
-
Incubation Time:48 h (MIH-36); 4 h (MTT)
-
Result:MIH-36 IC50 values were 18.9 μM in MDA-MB-231 cells, 13.74 μM in MCF-7 cells, and 49.40 μM in L929 cells.
MIH-36 selectivity indices were 2.61 for MDA-MB-231 and 3.59 for MCF-7.
-
Cell Line:MDA-MB-231 and MCF-7 cells
-
Concentration:IC50
-
Incubation Time:48 h
-
Result:In MDA-MB-231 cells, MIH-36 decreased live cells to Q4 68.6% and increased late apoptotic cells to Q2 24.7%.
In MCF-7 cells, MIH-36 increased late apoptotic cells to Q2 26.1%, decreased live cells to Q4 59.7%, with Q3 11.7% and Q1 2.49%.
-
Cell Line:MDA-MB-231 cells
-
Concentration:Various concentrations
-
Incubation Time:48 h (MIH-36); PCR cycling as described
-
Result:Significantly increased VEGFR-2 mRNA expression compared with both the control group and the DMSO group.
Chemical Information
-
Masse moléculaire 545.41
-
Formule C21H13F6N5O4S
-
SMILES
S=C(NC1=CC=C(C(N/N=C/C2=CC=C([N+]([O-])=O)O2)=O)C=C1)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MIH-36 Related Classifications
HY-189691 Related Classifications
Powered by Bioz