MK2-IN-5
Based on 1 publication(s) in Google Scholar
MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation.
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- CAS No.: 474713-20-7
- Formule: C61H113N21O16
- Masse moléculaire:1396.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) MK2-IN-5
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Activité biologique
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ERK1 |
ERK2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ventilator-associated lung injury model[2]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Decreased HSP25 phosphorylation.
Chemical Information
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CAS No. 474713-20-7
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Masse moléculaire 1396.68
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Formule C61H113N21O16
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Synonyms
Hsp25 kinase inhibitor; Mk2 pseudosubstrate
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Sequence
Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
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Sequence Shortening
KKKALNRQLGVAA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Enhancing CAR-T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF-Mediated Angiogenesis. [Abstract]2026 May 6:e21975. PMID: 42089445
Pureté et documentation
Références
[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [Content Brief]
[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [Content Brief]
[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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