MMK1 TFA
Based on 1 publication(s) in Google Scholar
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.
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- Formule: C75H123N19O18S.xC2HF3O2
- Masse moléculaire:1610.96 (free acid)
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MMK1 TFA
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Activité biologique
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Calcium Channel |
MMK-1 TFA induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with an EC50 of 2 nM[1].
MMK1 (1 μM; for 4 h) TFA induces selective migration of FPR2-expressing RBL-2H3 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old male ddY mice[4]
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Dosage:10, 100, 1000 pmol/mouse
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Administration:ICV; 20 min before the test
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Result:Exerted an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse.
Chemical Information
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Masse moléculaire 1610.96 (free acid)
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Formule C75H123N19O18S.xC2HF3O2
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Sequence
Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met
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Sequence Shortening
LESIFRSLLFRVM
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureté et documentation
Références
[1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7. [Content Brief]
[2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975. [Content Brief]
[3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664. [Content Brief]
[4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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