MNP2
MNP2 is a NLRP3-ASC interaction inhibitor. MNP2 selectively binds to the PYD domain of ASC (Ka=149 nM) and blocks ASC-PYM binding (Ka=58 nM), thereby inhibiting the interaction between ASC and NLRP3 and suppressing the formation of the NLRP3 inflammasome. MNP2 inhibits IL-1β release and caspase-1 maturation, and reduces the efflux of potassium and chloride ions. MNP2 prevents mitochondrial damage and reactive oxygen species production, and significantly decreases NLRP3 inflammasome formation in neurodegenerative pathologies induced by β-amyloid, Tau protein and α-synuclein. MNP2 is applicable for the research of neurodegenerative diseases.
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- Formule: C56H94N18O12
- Masse moléculaire:1211.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Caspase-1 |
IL-1β |
NLRP3 inflammasome |
α-synuclein |
MNP2 (20-100 μM; 24 h) potently inhibits NLRP3 inflammasome activation in N9 microglia, with an IC50 of 2.57 μM for IL-1β and 16.23 μM for caspase-1, while also resisting pyroptosis induced by 1 μg/mL LPS+ATP or LPS+Aβ/Tau/α-Syn[1].
MNP2 (100 μM; 24-48 h) remains stable for 48 hours in fetal bovine serum (FBS) and for 24 hours in human serum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N9 microglial cells
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Concentration:100 μM; stimulated with LPS (1 μg/mL), ATP (5 mM), Aβ oligomer (10 μM), Tau oligomer (5 μM), and α- Syn (5 μM)
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Incubation Time:24 h
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Result:Protected cells against pyroptosis induced by LPS+ATP or LPS+Aβ/Tau/α-Syn.
Chemical Information
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Masse moléculaire 1211.46
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Formule C56H94N18O12
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Sequence
Val-Trp-Ile-Leu-Ala-Ala-Ile-Asn-Arg-Arg
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Sequence Shortening
VWILAAINRR
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MNP2 Related Classifications
HY-P11581 Related Classifications
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