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Movronersen

(Synonyms: BIIB-101; ION-464)

Movronersen (BIIB-101; ION-464) is an antisense oligonucleotide that targets SNCA; it promotes the degradation of SNCA mRNA and downregulates the synthesis of α-synuclein. By reducing the production of α-synuclein, Movronersen decreases protein misfolding and aggregation, thereby interfering with the pathological progression of synucleinopathies. Movronersen is used in research related to multiple system atrophy and associated disorders.

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  • Movronersen Chemical Structure
    Movronersen Chemical Structure
CAS No.: 2411937-33-0
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  • Movronersen Chemical Structure
    Movronersen Chemical Structure DNA, d([2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]rA-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-G-sp-T-sp-T-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rC)
    1/16
  • DNA, d([2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]rA-sp-T-sp-A-sp-T-sp-T-sp-T-sp-T-sp-T-sp-G-sp-T-sp-T-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rC)