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Cat. No.: HY-115273

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MRS-2179

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM.

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CAS No.: 101204-49-3
Formule: C₁₁H₁₇N₅O₉P₂
Masse moléculaire:425.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MRS-2179 Chemical Structure

CAS No.: 101204-49-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM^[1].

IC₅₀ & Target

P2Y1 Receptor

Voir tous les produits spécifiques à Isoform P2Y Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	210 nM Compound: MRS-2179	Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	320 nM Compound: MRS-2179	Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	330 nM Compound: MRS-2179	Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	480 nM Compound: MRS-2179	Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	660 nM Compound: MRS-2179	Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	740 nM Compound: MRS-2179	Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	980 nM Compound: MRS-2179	Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	13 μM Compound: MRS-2179	The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes	[PMID: 12213051]

Chemical Information

CAS No. 101204-49-3
Masse moléculaire 425.23
Formule C₁₁H₁₇N₅O₉P₂
SMILES

CNC1=C2C(N([C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O[P](O)(O)=O)C3)C=N2)=NC=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mil Med Res

PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]

2024 Jun 27;11(1):41. PMID: 38937853
Int J Biol Macromol

Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality. [Abstract]

2025 Mar:296:139766. PMID: 39800030

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Moro S, et al., Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem. 1998 Apr 23;41(9):1456-66. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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Keywords

MRS-2179

2 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Pureté et documentation
Références

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MRS-2179

Publications Citing Use of MedChemExpress (MCE) MRS-2179

Voir tous les produits spécifiques à Isoform P2Y Receptor

Activité biologique

Chemical Information

Publications (2)

Pureté et documentation

Références

Calculators

Help & FAQs

MRS-2179 Related Classifications

HY-115273 Related Classifications