MT-44
MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer.
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- CAS No.: 2966790-70-3
- Formule: C26H23N5O4
- Masse moléculaire:469.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MT-44 exhibits potent antiproliferative activity against TNBC cells MDA-MB-231 and MDA-MB-468 with IC50 values of 66.5 nM and 148.2 nM respectively[1].
MT-44 (0.25-1.0 μM, 12-48 h) concentration-dependently inhibits the migration and induces G2/M phase arrest in MDA-MB-231 cells[1].
MT-44 (0.05-0.5 μM) significantly inhibits colony formation and invasion of MDA-MB-231 cells[1].
MT-44 (0.5-2.0 μM, 24 h) concentration-dependently induces apoptosis, promotes autophagy and increases intracellular ROS accumulation in MDA-MB-231 cells[1].
MT-44 (0.5-2.0 μM, 24h) downregulates the phosphorylation levels of p-P70S6K, p-Akt, and p-4EBP1and upregulates phosphorylated proteins in the cGAS/STING pathway in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0.5, 1 and 2 μM
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Incubation Time:24 h
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Result:Increased apoptotic cells.
Upregulated the expression of γ-H2AX and the ratio of BAX/BCL2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice with MDA-MB-231 xenografts[1]
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Dosage:10 and 20 mg/kg
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Administration:Intravenously injection, once every 3 days for 15 days
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Result:Showed tumor growth inhibition rates (TGI) of 38.64% and 72.73%.
Had obvious organ toxicity.
Downregulated phosphorylated proteins of the mTOR pathway in tumor tissues.
Activated the cGAS/STING pathway, increased NK cell infiltration, and reduced regulatory T cells and tumor-associated macrophages.
Chemical Information
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CAS No. 2966790-70-3
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Masse moléculaire 469.49
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Formule C26H23N5O4
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SMILES
COC1=CC=C2OC(C3=CC=C4N=C(OC4=C3)N)=C/C(C2=C1)=N\C5=CC=CC=C5NC(CCN)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MT-44 Related Classifications
HY-178431 Related Classifications
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