Nefopam
Based on 3 publication(s) in Google Scholar
Nefopam (Fenazoxine) is an orally active, non-opioid and non-steroidal centrally acting analgesic agent. Nefopam blocks voltage-sensitive sodium channels (IC50=27 μM) and modulates glutamatergic transmission in rodents. Nefopam can be used in studies of neuropathic pain, anticonvulsant, as well as the prevention of postoperative shivering and hiccups.
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- CAS No.: 13669-70-0
- Formule: C17H19NO
- Masse moléculaire:253.34
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Publications Citing Use of MedChemExpress (MCE) Nefopam
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Activité biologique
Nefopam (0.1-100 μM; 15 min) inhibits the uptake of 22Na in a concentration-dependent manner in SK-N-SH cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-N-SH cells
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Concentration:0.1-100 µM
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Incubation Time:15 min (preincubate)
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Result:Inhibited the uptake of 22Na with an IC50 value of 27 µM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male NMRI mice (25-30 g; 6 to7-week-old; electroshock-induced seizures model)[1]
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Dosage:0-10 mg/kg
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Administration:Intravenous injection; single
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Result:Produced dose-dependent protection against maximal electroshock seizures in mice with an ED50 of 3.8 (2.9-5.1) mg/kg.
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Animal Model:Adult male mice (10-week-old; 25-30 g; vincristine-induced peripheral neuropathy model)[2].
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Dosage:10, 30, 60 mg/kg
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Administration:Intraperitoneal injection; single
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Result:Significantly decreased the percentage of NK1 receptors in the spinal cord at dosage of 60 mg/kg.
Showed a sustained increase in paw withdrawal threshold against mechanical stimuli.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 13669-70-0
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Masse moléculaire 253.34
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Formule C17H19NO
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SMILES
CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1
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Synonyms
Fenazoxine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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ACS Omega
2020 Oct 12;5(41):26551-26561. PMID: 33110983 -
Sci Rep
2019 Jun 21;9(1):9005. PMID: 31227757 -
Mol Carcinog
KDM6A Exhibits Antitumor Activities Toward Ovarian Cancer by Epigenetically Activating Transcription of ISG-15. [Abstract]2025 Nov 18. PMID: 41252674
Pureté et documentation
Références
[1]. Verleye M, et al. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents. Brain Res. 2004 Jul 9;1013(2):249-55. [Content Brief]
[2]. Lee JY, et al. The Antiallodynic Effect of Nefopam on Vincristine-Induced Neuropathy in Mice. J Pain Res. 2020 Feb 7;13:323-329. [Content Brief]
[3]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nefopam Related Classifications
HY-133195 Related Classifications
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