NPC-14695
NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle.
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- CAS No.: 146561-59-3
- Formule: C24H30N2O2
- Masse moléculaire:378.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mAChR3 15 nM (Kd) |
mAChR2 60 nM (Kd) |
mAChR1 25 nM (Kd) |
In Vitro
NPC-14695 (1 nM-10 μM) inhibits carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 146561-59-3
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Masse moléculaire 378.51
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Formule C24H30N2O2
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SMILES
O=C(C(C1=CC=CC=C1)(C2CCC2)O)CN3CCN(CC3)CC4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NPC-14695 Related Classifications
HY-183932 Related Classifications
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