NSC1011
NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 5335-97-7
- Formule: C23H18N2O3
- Masse moléculaire:370.40
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
IC50: 6.9 µM (Rce1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
>10 μM
Compound: NC269, NSC 1011
|
Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 32830969] |
NSC1011 (25 µM; 20 h) induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 5335-97-7
-
Masse moléculaire 370.40
-
Formule C23H18N2O3
-
SMILES
O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC1011 Related Classifications
HY-122079 Related Classifications
Powered by Bioz