NSC727447
Based on 1 Customer Validation
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively.
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- Pureté: 95.0%
- CAS No.: 40106-12-5
- Formule: C10H14N2OS
- Masse moléculaire:210.30
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | CC50 |
19.9 μM
Compound: 1
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Cytotoxicity against human CEM-SS cells by XTT assay
Cytotoxicity against human CEM-SS cells by XTT assay
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[PMID: 20547794] |
| CEM-SS | IC50 |
4.3 μM
Compound: 1
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Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay
Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay
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[PMID: 20547794] |
Chemical Information
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CAS No. 40106-12-5
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Appearance Solid
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Masse moléculaire 210.30
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Formule C10H14N2OS
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Color Light brown to brown
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SMILES
O=C(C1=C(N)SC2=C1CCCCC2)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 50 mg/mL (237.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7551 mL | 23.7756 mL | 47.5511 mL | 118.8778 mL |
| 5 mM | 0.9510 mL | 4.7551 mL | 9.5102 mL | 23.7756 mL | |
| 10 mM | 0.4755 mL | 2.3776 mL | 4.7551 mL | 11.8878 mL | |
| 15 mM | 0.3170 mL | 1.5850 mL | 3.1701 mL | 7.9252 mL | |
| 20 mM | 0.2378 mL | 1.1888 mL | 2.3776 mL | 5.9439 mL | |
| 25 mM | 0.1902 mL | 0.9510 mL | 1.9020 mL | 4.7551 mL | |
| 30 mM | 0.1585 mL | 0.7925 mL | 1.5850 mL | 3.9626 mL | |
| 40 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9719 mL | |
| 50 mM | 0.0951 mL | 0.4755 mL | 0.9510 mL | 2.3776 mL | |
| 60 mM | 0.0793 mL | 0.3963 mL | 0.7925 mL | 1.9813 mL | |
| 80 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4755 mL | 1.1888 mL |
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