OP-1690
OP-1690 is a complete estrogen receptor (ERα) antagonist (CERAN), with pIC50 values of 7.5 and 7.9 in alkaline phosphatase (AP) activity assay and TR-FRET assay, respectively. OP-1690 modulates receptor function by inducing ERα tetramerization, effectively induces ERα degradation, inhibits target gene transcription, but exhibits low antiproliferative potency. OP-1690 can be used for breast cancer research.
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- Formule: C31H35ClF2N2O2
- Masse moléculaire:541.07
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
ERα 7.5 (pIC50) |
In Vitro
OP-1690 (7 d) inhibits the proliferation of MCF7 and CAMA-1 cells with pIC50 values of 6 and 5.9, respectively, which are lower than those of Fulvestrant (HY-13636) and RAD1901 (HY-19822).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
Chemical Information
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Masse moléculaire 541.07
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Formule C31H35ClF2N2O2
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SMILES
FC1=CC=CC=C1C2(CCCC2)CN(CC3=CC=CC(O)=C3Cl)C4=CC=C(OC5CN(CCCF)C5)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OP-1690 Related Classifications
HY-181345 Related Classifications
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