PhoFAP-02
PhoFAP-02 is a photodynamic therapy photosensitizer targeting FAP, assembled from a FAPI-04-derived targeting moiety, the DOTA chelator, and the photosensitizer IRDye700DX (HY-D2309). PhoFAP-02 produces photodynamic cytotoxicity against FAP-positive cells under 690 nm light irradiation. PhoFAP-02 can be radiolabeled with indium-111 and accumulates in FAP-high cancer-associated fibroblast stromal regions in mouse models of pancreatic cancer. PhoFAP-02 can be used in research related to targeted photodynamic therapy of pancreatic ductal adenocarcinoma.
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- Formule: C116H161F2N23O35S6Si3
- Masse moléculaire:2752.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
PhoFAP-02 (337.5-0.00075 nM; 2 h) inhibits the binding of [111In]In-FAPI-04 to 3T3-FAP cells with an IC50 of 27.75 nM[1].
PhoFAP-02 (0-1 nM; 2 h) induces concentration-dependent phototoxicity in 3T3-FAP cells after 690 nm irradiation, while not damaging 3T3-WT cells and showing no dark toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-FAP and 3T3-WT cells
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Concentration:1.0, 0.67, 0.44, 0.30, 0.20, 0 nM
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Incubation Time:2 h incubation; 5 min irradiation (60 J/cm2)
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Result:Induced concentration-dependent cell death in 3T3-FAP cells after 690 nm irradiation.
Did not reduce viability of light-exposed 3T3-WT cells and showed no detectable dark toxicity in 3T3-FAP cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 2752.30
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Formule C116H161F2N23O35S6Si3
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SMILES
O=C(N[C@H](C(N1CCN(CCCOC2=CC=C(N=CC=C3C(NCC(N4[C@H](C#N)CC(F)(F)C4)=O)=O)C3=C2)CC1)=O)CCCCNC(CCCCCNC(OCCCOC5=CC=CC6=C5C7=N/C6=N\C8=C(C=CC=C9)C9=C(/N=C%10C(C=CC=C%11)=C%11C%12=N/%10)N8[Si](O[Si](C)(C)CCC[N+](CCCS(=O)(O)=O)(CCCS(=O)([O-])=O)CCCS(=O)(O)=O)(O[Si](C)(CCC[N+](CCCS(O)(=O)=O)(CCCS(O)(=O)=O)CCCS([O-])(=O)=O)C)N(/C(C%13=C/%14C=CC=C%13)=N\%12)C%14=N/7)=O)=O)CN%15CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC%15
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PhoFAP-02 Related Classifications
HY-190471 Related Classifications
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Keywords
- PhoFAP-02
- PhoFAP02
- PhoFAP 02
- Photosensitizer
- FAP
- Drug Intermediate
- Fibroblast activation protein
- Drug Iintermediate
- FAP-expressing cells
- FAPI-derived targeting motif
- orthotopic PDAC tumors
- pancreatic ductal adenocarcinoma
- photodynamic cytotoxicity
- photosensitizer
- phototoxic cell death
- reactive oxygen species
- stromal regions
- Inhibitor
- inhibitor
- inhibit