CTGF
CTGF, also called CCN2, is a heparin-binding matricellular protein of the CCN family rather than a true IGF-binding protein, despite its catalog position. Secreted by fibroblasts, endothelial cells and chondrocytes, it carries four conserved modules — an insulin-like growth factor binding protein-like domain, a von Willebrand factor type C repeat, a thrombospondin type 1 repeat and a cystine knot — through which it engages integrins, heparan sulfate proteoglycans and other receptors. CTGF is a principal downstream mediator of TGF-beta in fibroblasts, driving extracellular matrix deposition, myofibroblast differentiation, angiogenesis and chondrogenesis. Sustained CTGF expression is a hallmark of fibrotic disorders of skin, lung, liver and kidney, and anti-CTGF antibodies are in clinical development for fibrosis.
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CTGF Protéines Recombinantes (9)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
