Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-189698
CAS No.: 2768833-33-4
Target:
Domaines de recherche:
NCTD-01 is an orally active NF-κB inhibitor. NCTD-01 inhibits TNF-α-induced NF-κB activation by preventing IκBα phosphorylation/degradation and nuclear translocation of NF-κB subunits, and inhibits LPS/IFN-γ-induced nitric oxide production in macrophages. NCTD-01 inhibits the differentiation of naive T cells into regulatory T cells, downregulates transcripts of pro-inflammatory and immunosuppressive mediators in colorectal tumor tissues, reduces serum pro-inflammatory cytokines, and decreases Treg-related inhibitory proteins in colorectal tissues. NCTD-01 can be used for research on colorectal cancer .
Target:
Domaines de recherche:
Doxylamine is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine is orally active, possessing analgesic and hypnotic activities. Doxylamine enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine can be used for the research of nausea, allergy, insomnia .
Synonyms: EDTA trisodium salt (Standard); Trisodium EDTA (Standard)
Target:
Domaines de recherche:
Ethylenediaminetetraacetic acid (trisodium salt) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (trisodium salt). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
Cat. No.: HY-B1455R
CAS No.: 18323-44-9
Clindamycin (Standard) is the analytical standard of Clindamycin. This product is intended for research and analytical applications. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .
Cat. No.: HY-B1455S
CAS No.: 1356933-72-6
Cat. No.: HY-D3111
CAS No.: 1240465-12-6
Target:
Domaines de recherche:
DBHA is a long-wavelength polarity-sensitive fluorescent probe based on Nile Red. Under the catalysis of Pd (OAc)2/TPPTS, DBHA site-selectively labels protein tyrosine residues via a π-allyl palladium complex intermediate. Utilizing the property that its maximum emission wavelength blue-shifts with decreasing local polarity (650 nm in aqueous solution → 584-608 nm in hydrophobic domains), it detects changes in local polarity and conformation of protein tyrosine domains under acid/thermal denaturation conditions. DBHA can be used in studies related to SOD1-associated oxidative stress neurodegenerative diseases .
Cat. No.: HY-N0060BS
CAS No.: 860605-59-0
Synonyms: (E)-Coniferic acid-d3
Category:
Cat. No.: HY-N6674
CAS No.: 733035-26-2
Synonyms: ECO-4601; TLN-4601; BU 4664L
Domaines de recherche:
Diazepinomicin (ECO-4601) is a reagent with both anticancer and antibacterial activities. . Diazepinomicin decreases Bcl2 and BAX expression, induces dose-dependent cell death and apoptotic bodies, and inhibits Ras-MAPK signaling and tumor growth/proliferation. Diazepinomicin induces apoptosis through caspase 3 activation, PARP cleavage, cytochrome C release, loss of membrane potential, and DNA fragmentation, independent of PBR expression. Diazepinomicin binds PBR/TSPO and displaces PK11195 through its farnesyl side chain rather than the dibenzodiazepinone core. Diazepinomicin can be used in research on hepatocellular carcinoma, Gram-positive bacterial infections, and glioma .
Cat. No.: HY-N7506
CAS No.: 178765-49-6
Synonyms: Delta3,2-Hydroxylbakuchiol
Cat. No.: HY-P11358
CAS No.: 159718-10-2
Domaines de recherche:
Cat. No.: HY-P4882
CAS No.: 183449-57-2
Target:
Domaines de recherche:
(Pyr3)-Amyloid β-Protein (3-42) is an N-terminally truncated and pyroglutamate-modified amyloid β peptide. (Pyr3)-Amyloid β-Protein (3-42) spontaneously aggregates into soluble oligomers and β-sheet-structured fibrils, causing neuronal cytotoxicity and leading to decreased expression of postsynaptic density protein 95 (PSD-95) in mouse cortex, thereby inducing synaptic dysfunction in spatial and short-term memory. (Pyr3)-Amyloid β-Protein (3-42) can be used for research on Alzheimer's disease .
Cat. No.: HY-P991025
CAS No.: 2927399-38-8
Synonyms: SNS-101; SNA 101
Solnerstotug (SNS-101; SNA 101) is a pH-sensitive humanized IgG1κ antibody targeting VISTA. The affinity of Solnerstotug for VISTA decreases continuously with increasing pH, with KD values of 0.35 nM and 353 nM at pH 5.8 and pH 7.4, respectively. Solnerstotug reshapes the tumor microenvironment by selectively blocking the interaction of VISTA with receptors such as PSGL-1 (IC50 = 6.7 nM) in acidic environments, polarizing macrophages toward a pro-inflammatory M1-like phenotype and increasing intratumoral CD8 + T cell infiltration. Solnerstotug can be used for cancer research .
Cat. No.: HY-P991595
CAS No.: 2790610-50-1
Target:
Domaines de recherche:
Cat. No.: HY-W145486
CAS No.: 299-28-5
Cat. No.: HY-W271506
CAS No.: 10135-38-3
Synonyms: 3,3,5,5-Tetramethyl-1-pyrroline 1-oxide
Domaines de recherche:
TMPO (3,3,5,5-Tetramethyl-1-pyrroline 1-oxide) is a spin trap targeting free radicals. TMPO is capable of scavenging superoxide, hydroxyl radicals and inhibits thymocyte apoptosis with EC50 values of 19.1 mM (MPS-induced) to 30.7 mM (Etoposide-induced) for inhibiting DNA fragmentation. TMPO reacts with intracellular free radicals to form stable nitroxide radical products, reducing oxidative stress (e.g., decreasing peroxide levels, maintaining glutathione content) and blocking oxidative events in the apoptotic pathway. TMPO is promising for research of apoptosis in immune cells like thymocytes .
Cat. No.: HY-W283930
CAS No.: 132858-26-5
Domaines de recherche:
YHV98-4 is a selective, blood-brain barrier-permeable Hv1 inhibitor with an IC50 of 0.7 μM. YHV98-4 reduces ROS production and restores the SHP-1-pAKT signaling pathway. YHV98-4 decreases the spread of hyperphosphorylated Tau protein. YHV98-4 alleviates inflammation and produces analgesic effects. YHV98-4 improves cognitive function in mouse models of Alzheimer's disease. YHV98-4 can be used in research related to inflammatory pain, neuropathic pain and Alzheimer's disease .
Cat. No.: HY-W414644
CAS No.: 229977-93-9
Target:
Domaines de recherche:
Infection Neurological Disease Inflammation/Immunology Cancer
Fluacrypyrim, a Miticide, is a STAT3 inhibitor. Fluacrypyrim significantly increases the protein tyrosine phosphatases(PTPs) activity. Fluacrypyrim inhibits the growth of leukemia cells by a predominant G1 arrest with significant decrease of the protein and mRNA levels of cyclin D1. Fluacrypyrim selectively inhibits STAT3 signaling, inducing growth arrest and apoptosis in STAT3-dependent cancer cells. Fluacrypyrim mitigates IR-induced hematopoietic system injury mainly by preventing apoptosis in the HSCs. Fluacrypyrim demonstrates significant analgesic and anti-inflammatory effects by inhibiting uterine smooth muscle contraction and inflammatory responses .
Cat. No.: HY-W419589
CAS No.: 16545-23-6
Domaines de recherche:
Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1 .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
