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Cat. No.: HY-131865

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SJF-1521

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Based on 1 Customer Validation

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research.
(Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.65%
CAS No.: 2230821-40-4
Formule: C₅₇H₆₁ClFN₇O₉S
Masse moléculaire:1074.65

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SJF-1521 Chemical Structure

CAS No.: 2230821-40-4

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research^[1]. (Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).

IC₅₀ & Target^[1]

VHL

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform EGFR :

In Vitro

SJF-1521 (25 nM-10 μM; 24 h) selectively degrades EGFR in OVCAR8 cells, while it has no effect on HER2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

OVCAR8 cells
Concentration:

25 nM, 100 nM, 250 nM, 1 μM, 2.5 μM, 10 μM
Incubation Time:

24 h
Result:

Significantly reduced the levels of EGFR, and did not affect the levels of HER2.

Chemical Information

CAS No. 2230821-40-4
Appearance Solid
Masse moléculaire 1074.65
Formule C₅₇H₆₁ClFN₇O₉S
Color Light green to yellow
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : ≥ 200 mg/mL (186.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9305 mL

4.6527 mL

9.3054 mL

5 mM

0.1861 mL

0.9305 mL

1.8611 mL

10 mM

0.0931 mL

0.4653 mL

0.9305 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Burslem GM,et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9305 mL	4.6527 mL	9.3054 mL	23.2634 mL
	5 mM	0.1861 mL	0.9305 mL	1.8611 mL	4.6527 mL
	10 mM	0.0931 mL	0.4653 mL	0.9305 mL	2.3263 mL
	15 mM	0.0620 mL	0.3102 mL	0.6204 mL	1.5509 mL
	20 mM	0.0465 mL	0.2326 mL	0.4653 mL	1.1632 mL
	25 mM	0.0372 mL	0.1861 mL	0.3722 mL	0.9305 mL
	30 mM	0.0310 mL	0.1551 mL	0.3102 mL	0.7754 mL
	40 mM	0.0233 mL	0.1163 mL	0.2326 mL	0.5816 mL
	50 mM	0.0186 mL	0.0931 mL	0.1861 mL	0.4653 mL
	60 mM	0.0155 mL	0.0775 mL	0.1551 mL	0.3877 mL
	80 mM	0.0116 mL	0.0582 mL	0.1163 mL	0.2908 mL
	100 mM	0.0093 mL	0.0465 mL	0.0931 mL	0.2326 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

SJF-1521

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

SJF-1521

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Bioactive Compound Library Max

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

SJF-1521 Related Classifications

HY-131865 Related Classifications