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Tanezumab

(Synonyms: RN-624; PF 4383119)
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Based on 1 publication(s) in Google Scholar

Tanezumab (RN-624) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia.

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  • Pureté: 99.52%
  • CAS No.: 880266-57-9
  • Masse moléculaire:145.44 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tanezumab
  • Experimental Validation Results for Tanezumab
  • Experimental Validation Results for Tanezumab
  • Tanezumab Chemical Structure
    Tanezumab Chemical Structure
CAS No.: 880266-57-9
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[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Immobilized Beta-NGF Protein, Human, HEK293, HY-P7660 can bind Tanezumab. The EC50 for this effect is 5.218 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 SHSY5Y cells labeling Tanezumab (HY-P99221, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Tanezumab Chemical Structure
    1/16
  • Tanezumab
  • Immobilized Beta-NGF Protein, Human, HEK293, HY-P7660 can bind Tanezumab. The EC50 for this effect is 5.218 ng/mL.
  • Flow cytometric analysis of 1.5×106 SHSY5Y cells labeling Tanezumab (HY-P99221, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).