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TGN-020

25 Cited Publications
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Based on 25 publication(s) in Google Scholar

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.

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  • Pureté: 99.97%
  • CAS No.: 51987-99-6
  • Formule: C8H6N4OS
  • Masse moléculaire:206.23
  • Stockage:

    Store at room temperature 3 years.

    In solvent   -80°C, 2 years , -20°C, 1 year
  • TGN-020 Chemical Structure
    TGN-020 Chemical Structure
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
  • Experimental Validation Results for TGN-020
CAS No.: 51987-99-6
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  • TGN-020 Chemical Structure
    TGN-020 Chemical Structure
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  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative T2WI and DWI images of three distinct mouse groups.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     Schematic of intracerebral injection procedure in mice. Representative fluorescence microscopy images show Ovalbumin (45-kDa, red) inflow into CSF at 30- and 60-minute. The white arrow indicates the residual tracer deposition. Scale bar: 1000 μm. Quantification of Ovalbumin inflow at 30- and 60-minute in brain sections (n = 4 mice per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 20:S2090-1232(25)00316-9. [Abstract]

    Customer Validation
     TGN-020 (0.1 mg/20 g, administered via intraperitoneal injection every 12 h). Representative Western blot bands and densitometric quantification of AQP4-M1 and AQP4-M23 in the peri-infarction area (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p.,on the third day) Representative immunoblot bands and densitometric quantification of TH, GFAP, AQP4-M1, AQP4-M23, and AQP4-M23/M1 (n = 6 per group).

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     TGN-020 (100 mg/kg, i.p., on the third day).Representative 20 × magnification immunofluorescence images of AQP4 (red) and GFAP (green) in the striatum and SN. White dotted squares show the colocalization of AQP4 with astrocyte endfeet.

  • 1/16

    TGN-020 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Feb:56:125-136. [Abstract]

    Customer Validation
     Quantification of the mean intensity of A594 penetration into the whole brain parenchyma in both Saline and MPTP groups after inhibition of TGN-020 (100 mg/kg, i.p., on the third day) (n = 4–5 per group).

  • TGN-020