Trichodimerol
Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock.
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- CAS No.: 145174-90-9
- Formule: C28H32O8
- Masse moléculaire:496.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
28.5 μM
Compound: 16
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Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay
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[PMID: 21146414] |
| K562 | IC50 |
47.8 μM
Compound: 16
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Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay
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[PMID: 21146414] |
| K562 | IC50 |
74.4 μM
Compound: 16
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Cytotoxicity against human K562 cells after 24 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
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[PMID: 21146414] |
| U-937 | IC50 |
16.5 μM
Compound: 16
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Cytotoxicity against human U937 cells after 24 hrs by MTT assay
Cytotoxicity against human U937 cells after 24 hrs by MTT assay
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[PMID: 21146414] |
Trichodimerol (BMS-182123) (concentrations leading to >99% inhibition; ~20 h) concentration-dependently inhibits LPS-induced TNF-α production in murine RAW 264.7 macrophages with an IC50 of 600 ng/mL[1].
Trichodimerol (BMS-182123) (0.1-4.0 μg/mL; 2 h) concentration-dependently inhibits LPS-induced TNF-α production in human peripheral blood monocytes with an IC50 of 4.0 μg/mL[1].
Trichodimerol (BMS-182123) (concentrations leading to full inhibition; 18-20 h) concentration-dependently inhibits LPS-induced human TNF-α promoter activity in transfected murine RAW macrophages with an IC50 of 200 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine macrophages
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Concentration:2 μg/mL
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Incubation Time:4 h
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Result:Significantly reduced LPS-induced steady-state TNF-α mRNA expression in murine macrophages without altering mRNA stability.
Chemical Information
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CAS No. 145174-90-9
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Masse moléculaire 496.55
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Formule C28H32O8
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SMILES
C[C@@]12[C@@]3([H])[C@]4([C@@](O1)([C@]5(O[C@@]2([C@@](C(O)=C3C(/C=C/C=C/C)=O)([C@@]5([H])C(C(/C=C/C=C/C)=O)=C4O)C)O)C)O)C
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Synonyms
BMS-182123
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trichodimerol Related Classifications
HY-N12104 Related Classifications
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