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Cat. No.: HY-165600A

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Trimedoxime

(Synonyms: TMB-4)

Trimedoxime (TMB-4) is a blood-brain barrier-permeable cholinesterase reactivator. Trimedoxime reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime reduces mortality and prolongs survival time. Trimedoxime exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning.

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CAS No.: 56-97-3
Formule: C₁₅H₁₈Br₂N₄O₂
Masse moléculaire:446.14

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Trimedoxime Chemical Structure

CAS No.: 56-97-3

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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

In Vivo

Trimedoxime (25 µM per rat; i.p.; single administration) exerts a protective effect against paraoxon-induced death in male Wistar rats^[1].
Trimedoxime (7.5 mg/kg; i.m.; single dose) significantly reactivates acetylcholinesterase (AChE) inhibited by tabun in rat blood and diaphragm, with reactivation rates of 17.5% and 34.7%, respectively, but exerts extremely weak reactivation on this enzyme in rat brain (only 2.8%), and reduces the acute lethal effect of tabun in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 200-250 g, organophosphate poisoning model via intraperitoneal paraoxon exposure)^[1]
Dosage:

25 µM/rat
Administration:

i.p.; single dose
Result:

Reduced 48-hour mortality to 38% in rats exposed to 1 µmol/rat paraoxon.
Reduced 48-hour mortality to 76% in rats exposed to 10 µmol/rat paraoxon.
Reduced 48-hour mortality to 83% in rats exposed to 15 µmol/rat paraoxon.
Lowered the relative risk of death to 0.36 (95% confidence interval, 0.26 to 0.50) compared to paraoxon-only controls.

Animal Model:

Wistar (male, 180-200 g, tabun poisoning model)^[3]
Dosage:

7.5 mg/kg
Administration:

i.m.; single prophylactic dose
Result:

Produced 17.5% reactivation of tabun-inhibited AChE in blood.
Produced 34.7% reactivation of tabun-inhibited AChE in diaphragm.
Produced 2.8% reactivation of tabun-inhibited AChE in brain.
Showed significant differences from atropine-only control and HI-6 treatment group.
Increased the LD50 of tabun in mice to 504.8 μg/kg.
Resulted in a protective ratio of 1.71.
Showed significant difference from untreated group and HI-6 treatment group.

Chemical Information

CAS No. 56-97-3
Masse moléculaire 446.14
Formule C₁₅H₁₈Br₂N₄O₂
SMILES

O/N=C/C1=CC=[N+](CCC[N+]2=CC=C(C=C2)/C=N/O)C=C1.[Br-].[Br-]
Synonyms

TMB-4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nela Váňová, et al. In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. 2023 Dec 18; 36(12): 1912–1920. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Trimedoxime

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

Activité biologique

Chemical Information

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Trimedoxime Related Classifications

HY-165600A Related Classifications