TUG-905
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression.
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- CAS No.: 1390641-90-3
- Formule: C27H30FNO5S
- Masse moléculaire:499.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
pEC50: 7.03 (GPR40)[1]
TUG-905 (10 µM; 7, 13 days) increases cell proliferation and DCX mRNA levels of the neuroblast marker[2].
TUG-905 (10 µM; 2, 4, 24 h) increases GPR40, BDNF gene expression in Neuro2a (murine neuroblastoma) cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DCX/GFAP positive cells (neurospheres from mouse hypothalamic tissue)
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Concentration:10 µM
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Incubation Time:7 days
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Result:Increased mRNA levels of the neuroblast marker, DCX, as well as the number of DCX-immunopositive cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6 weeks, Male Swiss mice[1]
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Dosage:2.0 μL, 1.0 mM
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Administration:I.c.v.; twice a day for 6 days
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Result:Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression.
Chemical Information
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CAS No. 1390641-90-3
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Masse moléculaire 499.59
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Formule C27H30FNO5S
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SMILES
O=C(CCC1=CC=C(C=C1F)NCC2=CC(C3=CC=C(C=C3C)OCCCS(=O)(C)=O)=CC=C2)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. [Content Brief]
[2]. Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TUG-905 Related Classifications
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