Ulodesine succinate
Based on 1 publication(s) in Google Scholar
Ulodesine succinate is a purine nucleoside phosphorylase (PNP) inhibitor, with an IC50 of 2.293 nM against human PNP, and low nanomolar IC50 values against mouse, rat and monkey PNP. Ulodesine succinate blocks the production of uric acid precursors, reduces serum uric acid levels, clears accumulated uric acid in the blood, and elevates the levels of purine nucleosides including guanosine. Ulodesine succinate reduces the counts of total lymphocytes, T lymphocytes and lymphocyte subsets, inhibits the proliferation of cancer cells and activated lymphocytes, and enhances vaccine immune responses. Ulodesine succinate can be used in research related to hyperuricemia and gout.
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- CAS No.: 1246200-39-4
- Formule: C12H16N4O3·1/2C4H6O4
- Masse moléculaire:323.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Ulodesine succinate
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Activité biologique
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PNP 2.293 nM (IC50) |
Ulodesine succinate exhibits potent nanomolar-range inhibitory activity against PNP, with an IC50 of 2.293 nmol/L[1].
Ulodesine succinate (low nM) potently inhibits PNP and blocks proliferation of T-ALL cell lines at low nM concentrations, inhibits activated normal PBLs with lower potency, and has no effect on HUT102 CTCL cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1246200-39-4
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Masse moléculaire 323.33
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Formule C12H16N4O3·1/2C4H6O4
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SMILES
OC(CCC(O)=O)=O.O=C(N=CN1)C2=C1C(CN3C[C@@H]([C@H](C3)O)CO)=CN2.[1/2]
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Synonyms
BCX4208 succinate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Gut Microbes
Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation. [Abstract]2026 Dec 31;18(1):2620124. PMID: 41605881
Pureté et documentation
Références
[1]. van der Meer JW, et al. Abstract!. The Netherlands journal of medicine. 2002 Dec;60(11):418. [Content Brief]
[2]. Shahid H, et al. Investigational drugs for hyperuricemia. Expert opinion on investigational drugs. 2015;24(8):1013-30. [Content Brief]
[4]. Tang DH, et al. Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model. Pharm Biol. 2021 Dec;59(1):175-182. [Content Brief]
[5]. Evans GB, et al. Immucillins in Infectious Diseases. ACS infectious diseases. 2018 Feb 09;4(2):107-117. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ulodesine succinate Related Classifications
HY-19480B Related Classifications
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