VCP171
Based on 1 Customer Validation
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain.
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- Pureté: 99.18%
- CAS No.: 1018830-99-3
- Formule: C18H12F3NOS
- Masse moléculaire:347.35
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
A1R |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | ED50 |
15.8 μM
Compound: 6b
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Activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as agonist-receptor ternary complex remaining by [35S]GTPgammaS binding assay
Activity at human adenosine A1 receptor expressed in CHOK1 cells assessed as agonist-receptor ternary complex remaining by [35S]GTPgammaS binding assay
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[PMID: 17980606] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neurons from male Sprague-Dawley rats (5-6 weeks; performed a partial nerve ligation (PNL) of the left sciatic nerve to create neuropathic pain model)[1]
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Dosage:10 μM
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Administration:0-30 min
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Result:Reduced AMPAR-mediated evoked excitatory postsynaptic current (eEPSCs) in Lamina I cells in sham (13±2%, n=7 cells) and nerve-injured animals (24±4%, n=8 cells) compared with predrug controls; increased paired pulse ration in cells from sham control animals; was significantly more effective in Lamina II neurons from nerve-injured animals than sham controls.
Chemical Information
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CAS No. 1018830-99-3
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Appearance Solid
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Masse moléculaire 347.35
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Formule C18H12F3NOS
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Color Light yellow to yellow
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SMILES
O=C(C1=C(N)SC=C1C2=CC(C(F)(F)F)=CC=C2)C3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (287.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8789 mL | 14.3947 mL | 28.7894 mL | 71.9735 mL |
| 5 mM | 0.5758 mL | 2.8789 mL | 5.7579 mL | 14.3947 mL | |
| 10 mM | 0.2879 mL | 1.4395 mL | 2.8789 mL | 7.1974 mL | |
| 15 mM | 0.1919 mL | 0.9596 mL | 1.9193 mL | 4.7982 mL | |
| 20 mM | 0.1439 mL | 0.7197 mL | 1.4395 mL | 3.5987 mL | |
| 25 mM | 0.1152 mL | 0.5758 mL | 1.1516 mL | 2.8789 mL | |
| 30 mM | 0.0960 mL | 0.4798 mL | 0.9596 mL | 2.3991 mL | |
| 40 mM | 0.0720 mL | 0.3599 mL | 0.7197 mL | 1.7993 mL | |
| 50 mM | 0.0576 mL | 0.2879 mL | 0.5758 mL | 1.4395 mL | |
| 60 mM | 0.0480 mL | 0.2399 mL | 0.4798 mL | 1.1996 mL | |
| 80 mM | 0.0360 mL | 0.1799 mL | 0.3599 mL | 0.8997 mL | |
| 100 mM | 0.0288 mL | 0.1439 mL | 0.2879 mL | 0.7197 mL |
VCP171 Related Classifications
HY-113608 Related Classifications
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