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Cat. No.: HY-P11606

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WNT3Ap

WNT3Ap is a polypeptide corresponding to the hairpin 2 domain of the WNT3A protein. WNT3Ap undergoes palmitoylation modification catalyzed by PORCN. WNT3Ap is a key compound for elucidating the molecular mechanism of the Wnt signaling pathway and for developing PORCN inhibitors.

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Formule: C₁₀₈H₁₆₄N₃₂O₂₈S₅
Masse moléculaire:2518.98

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Please store the product under the recommended conditions in the Certificate of Analysis.

WNT3Ap Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Wnt :

In Vitro

WNT3Ap (50 μM; 37°C for 30 minutes) undergoes acylation by PORCN in vitro, with a Km value of 14.29 μM for palmitoyl-CoA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 2518.98
Formule C₁₀₈H₁₆₄N₃₂O₂₈S₅
Sequence

Met-His-Leu-Lys-Cys-Lys-Cys-His-Gly-Leu-Ser-Gly-Ser-Cys-Glu-Val-Lys-Thr-Cys-Trp-Trp-Ser-NH2 (Disulfide bridge:Cys5-Cys19,Cys7-Cys14)
Sequence Shortening

MHLKCKCHGLSGSCEVKTCWWS-NH2 (Disulfide bridge:Cys5-Cys19,Cys7-Cys14)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu Y, et al. Mechanisms and inhibition of Porcupine-mediated Wnt acylation. Nature. 2022;607(7920):816-822. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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WNT3Ap

Voir tous les produits spécifiques à Isoform Wnt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

WNT3Ap Related Classifications

HY-P11606 Related Classifications